Reprogramming plant specialized metabolism by manipulating protein kinases

Ruiqing Lyu, Sanjay K. Singh, Yongliang Liu, Barunava Patra, Yan Zhou, Bingwu Wang, Sitakanta Pattanaik, Ling Yuan

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Being sessile, plants have evolved sophisticated mechanisms to balance between growth and defense to survive in the harsh environment. The transition from growth to defense is commonly achieved by factors, such as protein kinases (PKs) and transcription factors, that initiate signal transduction and regulate specialized metabolism. Plants produce an array of lineage-specific specialized metabolites for chemical defense and stress tolerance. Some of these molecules are also used by humans as drugs. However, many of these defense-responsive metabolites are toxic to plant cells and inhibitory to growth and development. Plants have, thus, evolved complex regulatory networks to balance the accumulation of the toxic metabolites. Perception of external stimuli is a vital part of the regulatory network. Protein kinase-mediated signaling activates a series of defense responses by phosphorylating the target proteins and translating the stimulus into downstream cellular signaling. As biosynthesis of specialized metabolites is triggered when plants perceive stimuli, a possible connection between PKs and specialized metabolism is well recognized. However, the roles of PKs in plant specialized metabolism have not received much attention until recently. Here, we summarize the recent advances in understanding PKs in plant specialized metabolism. We aim to highlight how the stimulatory signals are transduced, leading to the biosynthesis of corresponding metabolites. We discuss the post-translational regulation of specialized metabolism and provide insights into the mechanisms by which plants respond to the external signals. In addition, we propose possible strategies to increase the production of plant specialized metabolites in biotechnological applications using PKs.

Original languageEnglish
Pages (from-to)226-239
Number of pages14
JournalaBIOTECH
Volume2
Issue number3
DOIs
StatePublished - Sep 2021

Bibliographical note

Funding Information:
This work is supported partially by the Harold R. Burton Endowed Professorship to L.Y. and by the grant 2018530000241001 from the Yunnan Tobacco Company.

Publisher Copyright:
© 2021, Agricultural Information Institute, Chinese Academy of Agricultural Sciences.

Keywords

  • MAP kinase
  • Medicinal plants
  • Post-translational regulation
  • Protein kinases
  • Signal transduction
  • Specialized metabolites

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Agronomy and Crop Science
  • Genetics
  • Plant Science

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