TY - JOUR
T1 - Residual behavior and dietary risk assessment of albendazole as fungicide in citrus orchards
AU - Yang, Lihua
AU - Yao, Simin
AU - Fajar, Anugerah
AU - Merchant, Austin
AU - Shi, Jizhe
AU - Luo, Haifeng
AU - Qing, Zhaoxia
AU - Deng, Yaocheng
AU - Tang, Xiangwei
AU - Gong, Daoxin
AU - Zhou, Xuguo
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Albendazole is a broad-spectrum fungicide that shows great potential in controlling fungal diseases in citrus. To quantify the dissipation behavior, residue distribution, and dietary risk of albendazole in citrus, we developed an UPLC-MS/MS analysis protocol. The average recovery rate of albendazole in whole citrus and citrus pulp ranged from 74 to 105% with an RSD of 3 to 8%, and a limit of quantification of 0.01 mg kg−1. The degradation half-lives were 2.8–3.0 and 5.7–17.0 days in whole citrus and citrus pulp, respectively, and the final residues of albendazole were <0.059 mg kg−1 with a risk quotient of <1. This study not only demonstrates that the dietary risk of albendazole in citrus is negligible, but also provides empirical data to establish the maximum residual limit (MRL) for the safe application of albendazole in citrus orchards to meet the requirements for food safety as well as international trade.
AB - Albendazole is a broad-spectrum fungicide that shows great potential in controlling fungal diseases in citrus. To quantify the dissipation behavior, residue distribution, and dietary risk of albendazole in citrus, we developed an UPLC-MS/MS analysis protocol. The average recovery rate of albendazole in whole citrus and citrus pulp ranged from 74 to 105% with an RSD of 3 to 8%, and a limit of quantification of 0.01 mg kg−1. The degradation half-lives were 2.8–3.0 and 5.7–17.0 days in whole citrus and citrus pulp, respectively, and the final residues of albendazole were <0.059 mg kg−1 with a risk quotient of <1. This study not only demonstrates that the dietary risk of albendazole in citrus is negligible, but also provides empirical data to establish the maximum residual limit (MRL) for the safe application of albendazole in citrus orchards to meet the requirements for food safety as well as international trade.
KW - Albendazole
KW - Citrus
KW - Dietary risk assessment
KW - Dissipation behavior
KW - Residue distribution
KW - UPLC-MS/MS
UR - http://www.scopus.com/inward/record.url?scp=85152239498&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85152239498&partnerID=8YFLogxK
U2 - 10.1016/j.foodchem.2023.135796
DO - 10.1016/j.foodchem.2023.135796
M3 - Article
C2 - 37037131
AN - SCOPUS:85152239498
SN - 0308-8146
VL - 419
JO - Food Chemistry
JF - Food Chemistry
M1 - 135796
ER -