Residual behavior and dietary risk assessment of albendazole as fungicide in citrus orchards

Lihua Yang; Simin Yao; Anugerah Fajar; Austin Merchant; Jizhe Shi; Haifeng Luo; Zhaoxia Qing; Yaocheng Deng; Xiangwei Tang; Daoxin Gong; Xuguo Zhou

doi:10.1016/j.foodchem.2023.135796

Residual behavior and dietary risk assessment of albendazole as fungicide in citrus orchards

Lihua Yang
, Simin Yao
, Anugerah Fajar
, Austin Merchant
, Jizhe Shi
, Haifeng Luo
, Zhaoxia Qing
, Yaocheng Deng
, Xiangwei Tang
, Daoxin Gong
, Xuguo Zhou

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Albendazole is a broad-spectrum fungicide that shows great potential in controlling fungal diseases in citrus. To quantify the dissipation behavior, residue distribution, and dietary risk of albendazole in citrus, we developed an UPLC-MS/MS analysis protocol. The average recovery rate of albendazole in whole citrus and citrus pulp ranged from 74 to 105% with an RSD of 3 to 8%, and a limit of quantification of 0.01 mg kg⁻¹. The degradation half-lives were 2.8–3.0 and 5.7–17.0 days in whole citrus and citrus pulp, respectively, and the final residues of albendazole were <0.059 mg kg⁻¹ with a risk quotient of <1. This study not only demonstrates that the dietary risk of albendazole in citrus is negligible, but also provides empirical data to establish the maximum residual limit (MRL) for the safe application of albendazole in citrus orchards to meet the requirements for food safety as well as international trade.

Original language	English
Article number	135796
Journal	Food Chemistry
Volume	419
DOIs	https://doi.org/10.1016/j.foodchem.2023.135796
State	Published - Sep 1 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd

Funding

This work was supported by the Scientific Research Project of Hunan Provincial Department of Education China (Grant No. 19C0919) and the Agricultural Pesticide Residue Project of the Ministry of Agriculture of China (Grant No. 2018055).

Funders	Funder number
Scientific Research Project of Hunan Provincial Department of Education China	19C0919
Ministry of Agriculture of the People's Republic of China	2018055
Ministry of Agriculture of the People's Republic of China

Keywords

Albendazole
Citrus
Dietary risk assessment
Dissipation behavior
Residue distribution
UPLC-MS/MS

ASJC Scopus subject areas

Analytical Chemistry
Food Science

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10.1016/j.foodchem.2023.135796

Cite this

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title = "Residual behavior and dietary risk assessment of albendazole as fungicide in citrus orchards",

abstract = "Albendazole is a broad-spectrum fungicide that shows great potential in controlling fungal diseases in citrus. To quantify the dissipation behavior, residue distribution, and dietary risk of albendazole in citrus, we developed an UPLC-MS/MS analysis protocol. The average recovery rate of albendazole in whole citrus and citrus pulp ranged from 74 to 105\% with an RSD of 3 to 8\%, and a limit of quantification of 0.01 mg kg−1. The degradation half-lives were 2.8–3.0 and 5.7–17.0 days in whole citrus and citrus pulp, respectively, and the final residues of albendazole were <0.059 mg kg−1 with a risk quotient of <1. This study not only demonstrates that the dietary risk of albendazole in citrus is negligible, but also provides empirical data to establish the maximum residual limit (MRL) for the safe application of albendazole in citrus orchards to meet the requirements for food safety as well as international trade.",

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author = "Lihua Yang and Simin Yao and Anugerah Fajar and Austin Merchant and Jizhe Shi and Haifeng Luo and Zhaoxia Qing and Yaocheng Deng and Xiangwei Tang and Daoxin Gong and Xuguo Zhou",

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AU - Yang, Lihua

AU - Yao, Simin

AU - Fajar, Anugerah

AU - Merchant, Austin

AU - Shi, Jizhe

AU - Luo, Haifeng

AU - Qing, Zhaoxia

AU - Deng, Yaocheng

AU - Tang, Xiangwei

AU - Gong, Daoxin

AU - Zhou, Xuguo

PY - 2023/9/1

Y1 - 2023/9/1

N2 - Albendazole is a broad-spectrum fungicide that shows great potential in controlling fungal diseases in citrus. To quantify the dissipation behavior, residue distribution, and dietary risk of albendazole in citrus, we developed an UPLC-MS/MS analysis protocol. The average recovery rate of albendazole in whole citrus and citrus pulp ranged from 74 to 105% with an RSD of 3 to 8%, and a limit of quantification of 0.01 mg kg−1. The degradation half-lives were 2.8–3.0 and 5.7–17.0 days in whole citrus and citrus pulp, respectively, and the final residues of albendazole were <0.059 mg kg−1 with a risk quotient of <1. This study not only demonstrates that the dietary risk of albendazole in citrus is negligible, but also provides empirical data to establish the maximum residual limit (MRL) for the safe application of albendazole in citrus orchards to meet the requirements for food safety as well as international trade.

AB - Albendazole is a broad-spectrum fungicide that shows great potential in controlling fungal diseases in citrus. To quantify the dissipation behavior, residue distribution, and dietary risk of albendazole in citrus, we developed an UPLC-MS/MS analysis protocol. The average recovery rate of albendazole in whole citrus and citrus pulp ranged from 74 to 105% with an RSD of 3 to 8%, and a limit of quantification of 0.01 mg kg−1. The degradation half-lives were 2.8–3.0 and 5.7–17.0 days in whole citrus and citrus pulp, respectively, and the final residues of albendazole were <0.059 mg kg−1 with a risk quotient of <1. This study not only demonstrates that the dietary risk of albendazole in citrus is negligible, but also provides empirical data to establish the maximum residual limit (MRL) for the safe application of albendazole in citrus orchards to meet the requirements for food safety as well as international trade.

KW - Albendazole

KW - Citrus

KW - Dietary risk assessment

KW - Dissipation behavior

KW - Residue distribution

KW - UPLC-MS/MS

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Residual behavior and dietary risk assessment of albendazole as fungicide in citrus orchards

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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