Resistance in tuberculosis: What do we know and where can we go?

Keith D. Green, Sylvie Garneau-Tsodikova

Research output: Contribution to journalShort surveypeer-review

40 Scopus citations

Abstract

Tuberculosis (TB) has become a worldwide threat, mainly due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb). This mini-review is focused on the various mechanisms of resistance to the currently available anti-TB drugs and provides perspective on novel strategies and lead scaffolds/compounds aimed at inhibiting/overcoming these resistance mechanisms.

Original languageEnglish
JournalFrontiers in Microbiology
Volume4
Issue numberJUL
DOIs
StatePublished - 2013

Keywords

  • Antibiotics
  • Inhibitors
  • Mechanisms of resistance
  • New drug targets
  • Synergistic drug therapy

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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