TY - JOUR
T1 - Resistance in tuberculosis
T2 - What do we know and where can we go?
AU - Green, Keith D.
AU - Garneau-Tsodikova, Sylvie
PY - 2013
Y1 - 2013
N2 - Tuberculosis (TB) has become a worldwide threat, mainly due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb). This mini-review is focused on the various mechanisms of resistance to the currently available anti-TB drugs and provides perspective on novel strategies and lead scaffolds/compounds aimed at inhibiting/overcoming these resistance mechanisms.
AB - Tuberculosis (TB) has become a worldwide threat, mainly due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb). This mini-review is focused on the various mechanisms of resistance to the currently available anti-TB drugs and provides perspective on novel strategies and lead scaffolds/compounds aimed at inhibiting/overcoming these resistance mechanisms.
KW - Antibiotics
KW - Inhibitors
KW - Mechanisms of resistance
KW - New drug targets
KW - Synergistic drug therapy
UR - http://www.scopus.com/inward/record.url?scp=84885363975&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885363975&partnerID=8YFLogxK
U2 - 10.3389/fmicb.2013.00208
DO - 10.3389/fmicb.2013.00208
M3 - Short survey
C2 - 23888158
AN - SCOPUS:84885363975
SN - 1664-302X
VL - 4
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
IS - JUL
ER -
