Resources and Lymphocyte Terminal Maturity Among Older Adults

Suzanne C. Segerstrom, Rebecca G. Reed, Steven R. Presnell, Ahmad Al-Attar, Charles T. Lutz

Research output: Contribution to journalArticlepeer-review


Objective: Women’s financial resources were associated with more terminal maturity in natural killer lymphocytes, generally associated with loss of proliferative potential, during the “Great Recession”. This preregistered analysis expanded on that finding in a longitudinal design including both genders and examining the role of cytomegalovirus (CMV) serostatus. Method: Older adults (N = 138, 57% women) were assessed longitudinally during 2012–2017; including self-reported psychological, social, financial, and status-skill resources, CMV antibody titers and serostatus, and assessment of T and natural killer lymphocyte terminal maturity (LTM). Results: Neither total nor financial resources were associated with LTM. Adjusting only for age, more psychological resources (e.g., meaning, hope, humor) were associated with lower T LTM (percent: γ = -1.11 [-1.78, -.44]; number: γ = -.99 [-1.70, -.27]). There were no significant interactions with age, gender, or CMV serostatus; however, additionally adjusting for serostatus reduced the effect of psychological resources (percent: γ = -.41 [-93,.12]; number: (γ = -.40 [-.94,.13]). Conclusions: Outside the context of the “Great Recession”, psychological resources but not financial resources were associated with terminal maturity in T cells, a relationship related to CMV serostatus.

Original languageEnglish
Pages (from-to)46-52
Number of pages7
JournalHealth Psychology
Issue number1
StatePublished - Aug 18 2022

Bibliographical note

Funding Information:
This research was supported by the National Institute on Aging (R01-026307, K99/R00-AG056635). The authors have no conflicts of interest to disclose

Publisher Copyright:
© 2022 American Psychological Association


  • Aging
  • Immunosenescence
  • Latent infection
  • Psychoneuroimmunology
  • Well-being

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health


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