TY - JOUR
T1 - Response of neuroglia to hypoxia-induced oxidative stress using enzymatically crosslinked hydrogels
AU - Zambuto, Samantha G.
AU - Serrano, Julio F.
AU - Vilbert, Avery C.
AU - Lu, Yi
AU - Harley, Brendan A.C.
AU - Pedron, Sara
N1 - Publisher Copyright:
© Copyright Materials Research Society 2019.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Three-dimensional cultures have exciting potential to mimic aspects of healthy and diseased brain tissue to examine the role of physiological conditions on neural biomarkers, as well as disease onset and progression. Hypoxia is associated with oxidative stress, mitochondrial damage, and inflammation, key processes potentially involved in Alzheimer's and multiple sclerosis. We describe the use of an enzymatically-crosslinkable gelatin hydrogel system within a microfluidic device to explore the effects of hypoxia-induced oxidative stress on rat neuroglia, human astrocyte reactivity, and myelin production. This versatile platform offers new possibilities for drug discovery and modeling disease progression.
AB - Three-dimensional cultures have exciting potential to mimic aspects of healthy and diseased brain tissue to examine the role of physiological conditions on neural biomarkers, as well as disease onset and progression. Hypoxia is associated with oxidative stress, mitochondrial damage, and inflammation, key processes potentially involved in Alzheimer's and multiple sclerosis. We describe the use of an enzymatically-crosslinkable gelatin hydrogel system within a microfluidic device to explore the effects of hypoxia-induced oxidative stress on rat neuroglia, human astrocyte reactivity, and myelin production. This versatile platform offers new possibilities for drug discovery and modeling disease progression.
UR - http://www.scopus.com/inward/record.url?scp=85076906718&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85076906718&partnerID=8YFLogxK
U2 - 10.1557/mrc.2019.159
DO - 10.1557/mrc.2019.159
M3 - Article
AN - SCOPUS:85076906718
SN - 2159-6859
VL - 10
SP - 83
EP - 90
JO - MRS Communications
JF - MRS Communications
IS - 1
ER -
