Response to Bianco et al. Interaction forces between F-actin and titin PEVK domain measured with optical tweezers

Kenneth S. Campbell, Martin Lakiey

Research output: Contribution to journalLetterpeer-review

5 Scopus citations

Abstract

A recent publication in Biophysical Journal by Bianco et al. ("Interaction forces between F-actin and titin PEVK domain measured with optical tweezers") shows that the PEVK domain of titin molecules interacts with F-actin. This newly discovered behavior could influence the mechanical properties of striated muscles, and Bianco et al. suggest that the interactions between actin and titin could modulate thixotropic behavior. In this Comment to the Editor, we suggest that the thixotropic properties of striated muscles in vivo are more likely to reflect dynamic changes in the proportion of myosin cross-bridges bound between the myofilaments.

Original languageEnglish
Pages (from-to)327-328
Number of pages2
JournalBiophysical Journal
Volume94
Issue number1
DOIs
StatePublished - Jan 1 2008

Bibliographical note

Funding Information:
K.S.C. acknowledges support from American Heart Association SDG 0630079N, National Institutes of Health AG028162, and the University of Kentucky Research Challenge Trust Fund.

ASJC Scopus subject areas

  • Biophysics

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