TY - JOUR
T1 - Response to cyclosporine A in a patient with pure red cell aplasia due to antierythropoietin-α antibodies
AU - Fraer, Mony
AU - Campbell, Adam
AU - Sawaya, B. Peter
PY - 2006/5
Y1 - 2006/5
N2 - Reported cases of pure red cell aplasia (PRCA) from the administration of erythropoietin (EPO)-α molecule in the United States are rare, and the optimal treatment is still unknown. We present a patient with end-stage renal disease (ESRD) who became hyporesponsive and later unresponsive to EPO-α treatment a few months after initiation of hemodialysis. A comprehensive anemia examination was negative while the patient became transfusion dependent. The diagnosis of EPO-α-induced PRCA was confirmed by bone marrow biopsy, by undetectable serum EPO levels following the administration of a large dose of EPO-α, and by documenting the presence of EPO-neutralizing antibodies. Administration of cyclosporine A in addition to prednisone enabled the patient to become transfusion and EPO independent. This case further documents the possible occurrence of PRCA with EPO-α administration in the United States and reaffirms the potential beneficial effect of cyclosporine A.
AB - Reported cases of pure red cell aplasia (PRCA) from the administration of erythropoietin (EPO)-α molecule in the United States are rare, and the optimal treatment is still unknown. We present a patient with end-stage renal disease (ESRD) who became hyporesponsive and later unresponsive to EPO-α treatment a few months after initiation of hemodialysis. A comprehensive anemia examination was negative while the patient became transfusion dependent. The diagnosis of EPO-α-induced PRCA was confirmed by bone marrow biopsy, by undetectable serum EPO levels following the administration of a large dose of EPO-α, and by documenting the presence of EPO-neutralizing antibodies. Administration of cyclosporine A in addition to prednisone enabled the patient to become transfusion and EPO independent. This case further documents the possible occurrence of PRCA with EPO-α administration in the United States and reaffirms the potential beneficial effect of cyclosporine A.
UR - http://www.scopus.com/inward/record.url?scp=33646671469&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646671469&partnerID=8YFLogxK
U2 - 10.1111/j.1525-139X.2006.00163.x
DO - 10.1111/j.1525-139X.2006.00163.x
M3 - Article
C2 - 16689978
AN - SCOPUS:33646671469
SN - 0894-0959
VL - 19
SP - 251
EP - 255
JO - Seminars in Dialysis
JF - Seminars in Dialysis
IS - 3
ER -