TY - JOUR
T1 - Response to first dose of inhaled albuterol in mechanically ventilated preterm infants
AU - Raffay, Thomas M.
AU - Brasher, Mandy
AU - Place, Brooke C.
AU - Patwardhan, Abhijit
AU - Giannone, Peter J.
AU - Bada, Henrietta
AU - Westgate, Philip M.
AU - Abu Jawdeh, Elie G.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2021/7
Y1 - 2021/7
N2 - Background: Bronchodilator responses among preterm infants are heterogeneous. Bedside measurements may identify responders. Study design: Respiratory measurements (Resistance, Compliance, FiO2) and pulse oximetry (SpO2) patterns were downloaded from infants <30 weeks gestational age during the first 2 months of life. Mechanically ventilated infants who received albuterol were included (n = 33). Measurements were compared before and after first albuterol. Secondary analyses assessed subsequent doses. Results: Median gestation and birthweight were 25 3/7 weeks and 730 g, respectively. Mean Resistance decreased post-albuterol (p = 0.007). Sixty-eight percent of infants were responders based on decreased Resistance. Compliance and FiO2 did not significantly differ. Percent time in hypoxemia (SpO2< 85%) decreased post albuterol (p < 0.02). In responders, Resistance changes diminished with subsequent administration (all p = 0.01). Conclusions: Ventilator resistance decreased in two-thirds of preterm infants, consistent with studies that utilized formal pulmonary function testing. Albuterol had a variable effect on delivered FiO2; however, hypoxemia may be useful in evaluating albuterol response.
AB - Background: Bronchodilator responses among preterm infants are heterogeneous. Bedside measurements may identify responders. Study design: Respiratory measurements (Resistance, Compliance, FiO2) and pulse oximetry (SpO2) patterns were downloaded from infants <30 weeks gestational age during the first 2 months of life. Mechanically ventilated infants who received albuterol were included (n = 33). Measurements were compared before and after first albuterol. Secondary analyses assessed subsequent doses. Results: Median gestation and birthweight were 25 3/7 weeks and 730 g, respectively. Mean Resistance decreased post-albuterol (p = 0.007). Sixty-eight percent of infants were responders based on decreased Resistance. Compliance and FiO2 did not significantly differ. Percent time in hypoxemia (SpO2< 85%) decreased post albuterol (p < 0.02). In responders, Resistance changes diminished with subsequent administration (all p = 0.01). Conclusions: Ventilator resistance decreased in two-thirds of preterm infants, consistent with studies that utilized formal pulmonary function testing. Albuterol had a variable effect on delivered FiO2; however, hypoxemia may be useful in evaluating albuterol response.
UR - http://www.scopus.com/inward/record.url?scp=85106417144&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85106417144&partnerID=8YFLogxK
U2 - 10.1038/s41372-021-01071-0
DO - 10.1038/s41372-021-01071-0
M3 - Article
C2 - 34035457
AN - SCOPUS:85106417144
SN - 0743-8346
VL - 41
SP - 1704
EP - 1710
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 7
ER -