Responsiveness to curcumin intervention is associated with reduced aortic stiffness in young, obese men with higher initial stiffness

Marilyn S. Campbell; Adam J. Berrones; I. M. Krishnakumar; Richard J. Charnigo; Philip M. Westgate; Bradley S. Fleenor

doi:10.1016/j.jff.2016.12.013

Responsiveness to curcumin intervention is associated with reduced aortic stiffness in young, obese men with higher initial stiffness

Marilyn S. Campbell, Adam J. Berrones, I. M. Krishnakumar, Richard J. Charnigo, Philip M. Westgate, Bradley S. Fleenor

Research output: Contribution to journal › Article › peer-review

29 Citations (SciVal)

Abstract

Obesity results in greater aortic stiffness assessed by carotid-femoral Pulse Wave Velocity (cfPWV), which is an independent predictor of cardiovascular (CV) events. We hypothesized that a novel curcumin formulation with enhanced bioavailability, CurQfen®, would reduce cfPWV and inflammation in young, obese men. In the present placebo-controlled pilot study, 22 obese subjects (BMI ⩾ 30.0 kg/m²) were randomized into placebo (n = 11, BMI = 33.18 ± 3.38 kg/m²) and curcumin (n = 11, BMI = 33.29 ± 3.69 kg/m²) supplemented groups. When CurQfen® was supplemented at 500 mg/day for 12 weeks, it was found that individuals who did respond to the treatment (n = 6) entered the study with higher baseline cfPWV versus those who did not respond (n = 5) (6.81 ± 0.83 m/s v. 5.84 ± 0.41 m/s, p = 0.045, group by time interaction). The curcumin responders also had increased plasma IL-13 concentrations (p = 0.018, 12 weeks v. baseline). These findings suggest CurQfen curcumin has potential to de-stiffen arteries in young, obese men with greater aortic stiffness.

Original language	English
Pages (from-to)	154-160
Number of pages	7
Journal	Journal of Functional Foods
Volume	29
DOIs	https://doi.org/10.1016/j.jff.2016.12.013
State	Published - Feb 1 2017

Bibliographical note

Funding Information:
We would like to thank the staff in the CCTS for technical support with the study. We would also like to thank Drs. Mark Abel, Jody Clasey, and Travis Thomas for their insightful discussions and suggestions related to this study. This study was funded by Akay Flavours & Aromatics Pvt. Ltd., Arvle and Ellen Turner Thacker Research Fund, and was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through grant number UL1TR000117. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

Bioavailability
Body composition
Inflammation
Obesity
Turmeric
Vascular function

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jff.2016.12.013

Cite this

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title = "Responsiveness to curcumin intervention is associated with reduced aortic stiffness in young, obese men with higher initial stiffness",

abstract = "Obesity results in greater aortic stiffness assessed by carotid-femoral Pulse Wave Velocity (cfPWV), which is an independent predictor of cardiovascular (CV) events. We hypothesized that a novel curcumin formulation with enhanced bioavailability, CurQfen{\textregistered}, would reduce cfPWV and inflammation in young, obese men. In the present placebo-controlled pilot study, 22 obese subjects (BMI ⩾ 30.0 kg/m2) were randomized into placebo (n = 11, BMI = 33.18 ± 3.38 kg/m2) and curcumin (n = 11, BMI = 33.29 ± 3.69 kg/m2) supplemented groups. When CurQfen{\textregistered} was supplemented at 500 mg/day for 12 weeks, it was found that individuals who did respond to the treatment (n = 6) entered the study with higher baseline cfPWV versus those who did not respond (n = 5) (6.81 ± 0.83 m/s v. 5.84 ± 0.41 m/s, p = 0.045, group by time interaction). The curcumin responders also had increased plasma IL-13 concentrations (p = 0.018, 12 weeks v. baseline). These findings suggest CurQfen curcumin has potential to de-stiffen arteries in young, obese men with greater aortic stiffness.",

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author = "Campbell, {Marilyn S.} and Berrones, {Adam J.} and Krishnakumar, {I. M.} and Charnigo, {Richard J.} and Westgate, {Philip M.} and Fleenor, {Bradley S.}",

note = "Funding Information: We would like to thank the staff in the CCTS for technical support with the study. We would also like to thank Drs. Mark Abel, Jody Clasey, and Travis Thomas for their insightful discussions and suggestions related to this study. This study was funded by Akay Flavours & Aromatics Pvt. Ltd., Arvle and Ellen Turner Thacker Research Fund, and was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through grant number UL1TR000117. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

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AU - Charnigo, Richard J.

AU - Westgate, Philip M.

AU - Fleenor, Bradley S.

N1 - Funding Information: We would like to thank the staff in the CCTS for technical support with the study. We would also like to thank Drs. Mark Abel, Jody Clasey, and Travis Thomas for their insightful discussions and suggestions related to this study. This study was funded by Akay Flavours & Aromatics Pvt. Ltd., Arvle and Ellen Turner Thacker Research Fund, and was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through grant number UL1TR000117. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: © 2016 Elsevier Ltd

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Responsiveness to curcumin intervention is associated with reduced aortic stiffness in young, obese men with higher initial stiffness

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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