Responsiveness to curcumin intervention is associated with reduced aortic stiffness in young, obese men with higher initial stiffness

Marilyn S. Campbell, Adam J. Berrones, I. M. Krishnakumar, Richard J. Charnigo, Philip M. Westgate, Bradley S. Fleenor

Research output: Contribution to journalArticlepeer-review

29 Citations (SciVal)


Obesity results in greater aortic stiffness assessed by carotid-femoral Pulse Wave Velocity (cfPWV), which is an independent predictor of cardiovascular (CV) events. We hypothesized that a novel curcumin formulation with enhanced bioavailability, CurQfen®, would reduce cfPWV and inflammation in young, obese men. In the present placebo-controlled pilot study, 22 obese subjects (BMI ⩾ 30.0 kg/m2) were randomized into placebo (n = 11, BMI = 33.18 ± 3.38 kg/m2) and curcumin (n = 11, BMI = 33.29 ± 3.69 kg/m2) supplemented groups. When CurQfen® was supplemented at 500 mg/day for 12 weeks, it was found that individuals who did respond to the treatment (n = 6) entered the study with higher baseline cfPWV versus those who did not respond (n = 5) (6.81 ± 0.83 m/s v. 5.84 ± 0.41 m/s, p = 0.045, group by time interaction). The curcumin responders also had increased plasma IL-13 concentrations (p = 0.018, 12 weeks v. baseline). These findings suggest CurQfen curcumin has potential to de-stiffen arteries in young, obese men with greater aortic stiffness.

Original languageEnglish
Pages (from-to)154-160
Number of pages7
JournalJournal of Functional Foods
StatePublished - Feb 1 2017

Bibliographical note

Funding Information:
We would like to thank the staff in the CCTS for technical support with the study. We would also like to thank Drs. Mark Abel, Jody Clasey, and Travis Thomas for their insightful discussions and suggestions related to this study. This study was funded by Akay Flavours & Aromatics Pvt. Ltd., Arvle and Ellen Turner Thacker Research Fund, and was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through grant number UL1TR000117. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Publisher Copyright:
© 2016 Elsevier Ltd


  • Bioavailability
  • Body composition
  • Inflammation
  • Obesity
  • Turmeric
  • Vascular function

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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