TY - JOUR
T1 - REST/NRSF-Interacting LIM Domain Protein, a Putative Nuclear Translocation Receptor
AU - Shimojo, Masahito
AU - Hersh, Louis B.
PY - 2003/12
Y1 - 2003/12
N2 - The transcriptional repressor REST/NRSF (RE-1 silencing transcription factor/neuron-restrictive silencer factor) and the transcriptional regulator REST4 share an N-terminal zinc finger domain structure involved in nuclear targeting. Using this domain as bait in a yeast two-hybrid screen, a novel protein that contains three LIM domains, putative nuclear localization sequences, protein kinase A phosphorylation sites, and a CAAX prenylation motif was isolated. This protein, which is localized around the nucleus, is involved in determining the nuclear localization of REST4 and REST/NRSF. We propose the name RILP, for REST/NRSF-interacting LIM domain protein, to label this novel protein. RILP appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors.
AB - The transcriptional repressor REST/NRSF (RE-1 silencing transcription factor/neuron-restrictive silencer factor) and the transcriptional regulator REST4 share an N-terminal zinc finger domain structure involved in nuclear targeting. Using this domain as bait in a yeast two-hybrid screen, a novel protein that contains three LIM domains, putative nuclear localization sequences, protein kinase A phosphorylation sites, and a CAAX prenylation motif was isolated. This protein, which is localized around the nucleus, is involved in determining the nuclear localization of REST4 and REST/NRSF. We propose the name RILP, for REST/NRSF-interacting LIM domain protein, to label this novel protein. RILP appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors.
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U2 - 10.1128/MCB.23.24.9025-9031.2003
DO - 10.1128/MCB.23.24.9025-9031.2003
M3 - Article
C2 - 14645515
AN - SCOPUS:0345491828
SN - 0270-7306
VL - 23
SP - 9025
EP - 9031
JO - Molecular and Cellular Biology
JF - Molecular and Cellular Biology
IS - 24
ER -