Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet

Yolanda Jimenez-Gomez; Julie A. Mattison; Kevin J. Pearson; Alejandro Martin-Montalvo; Hector H. Palacios; Alex M. Sossong; Theresa M. Ward; Caitlin M. Younts; Kaitlyn Lewis; Joanne S. Allard; Dan L. Longo; Jonathan P. Belman; Maria M. Malagon; Placido Navas; Mitesh Sanghvi; Ruin Moaddel; Edward M. Tilmont; Richard L. Herbert; Christopher H. Morrell; Josephine M. Egan; Joseph A. Baur; Luigi Ferrucci; Jonathan S. Bogan; Michel Bernier; Rafael De Cabo

doi:10.1016/j.cmet.2013.09.004

Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet

Yolanda Jimenez-Gomez, Julie A. Mattison, Kevin J. Pearson, Alejandro Martin-Montalvo, Hector H. Palacios, Alex M. Sossong, Theresa M. Ward, Caitlin M. Younts, Kaitlyn Lewis, Joanne S. Allard, Dan L. Longo, Jonathan P. Belman, Maria M. Malagon, Placido Navas, Mitesh Sanghvi, Ruin Moaddel, Edward M. Tilmont, Richard L. Herbert, Christopher H. Morrell, Josephine M. EganJoseph A. Baur, Luigi Ferrucci, Jonathan S. Bogan, Michel Bernier, Rafael De Cabo

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Abstract

SUMMARY Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with antiinflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.

Original language	English
Pages (from-to)	533-545
Number of pages	13
Journal	Cell Metabolism
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.cmet.2013.09.004
State	Published - Oct 1 2013

Bibliographical note

Funding Information:
This work was funded by the Intramural Research Program of the National Institute on Aging, NIH; the Office of Dietary Supplements, NIH; and by the NIH R01 DK075772 (to J.S.B.) and F30 DK093198 (to J.P.B.). Y.J.-G. was supported by a Sara Borrell fellowship of the Institute de Salud Carlos III (CD07/00208) and by a grant for actividades y estancias formativas of the Consejeria de Salud, Junta de Andalucia (EF-0122/2010), Spain. The authors would like to thank DSM Nutritional Products for providing the resveratrol (resVida). None of the authors have any conflict of interest that could affect the performance of the work or the interpretation of the data.

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmet.2013.09.004

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Jimenez-Gomez, Y., Mattison, J. A., Pearson, K. J., Martin-Montalvo, A., Palacios, H. H., Sossong, A. M., Ward, T. M., Younts, C. M., Lewis, K., Allard, J. S., Longo, D. L., Belman, J. P., Malagon, M. M., Navas, P., Sanghvi, M., Moaddel, R., Tilmont, E. M., Herbert, R. L., Morrell, C. H., ... De Cabo, R. (2013). Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metabolism, 18(4), 533-545. https://doi.org/10.1016/j.cmet.2013.09.004

@article{c9451ae0c04d4ba5b179f1630596155c,

title = "Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet",

abstract = "SUMMARY Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with antiinflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.",

author = "Yolanda Jimenez-Gomez and Mattison, {Julie A.} and Pearson, {Kevin J.} and Alejandro Martin-Montalvo and Palacios, {Hector H.} and Sossong, {Alex M.} and Ward, {Theresa M.} and Younts, {Caitlin M.} and Kaitlyn Lewis and Allard, {Joanne S.} and Longo, {Dan L.} and Belman, {Jonathan P.} and Malagon, {Maria M.} and Placido Navas and Mitesh Sanghvi and Ruin Moaddel and Tilmont, {Edward M.} and Herbert, {Richard L.} and Morrell, {Christopher H.} and Egan, {Josephine M.} and Baur, {Joseph A.} and Luigi Ferrucci and Bogan, {Jonathan S.} and Michel Bernier and {De Cabo}, Rafael",

note = "Funding Information: This work was funded by the Intramural Research Program of the National Institute on Aging, NIH; the Office of Dietary Supplements, NIH; and by the NIH R01 DK075772 (to J.S.B.) and F30 DK093198 (to J.P.B.). Y.J.-G. was supported by a Sara Borrell fellowship of the Institute de Salud Carlos III (CD07/00208) and by a grant for actividades y estancias formativas of the Consejeria de Salud, Junta de Andalucia (EF-0122/2010), Spain. The authors would like to thank DSM Nutritional Products for providing the resveratrol (resVida). None of the authors have any conflict of interest that could affect the performance of the work or the interpretation of the data. ",

year = "2013",

month = oct,

day = "1",

doi = "10.1016/j.cmet.2013.09.004",

language = "English",

volume = "18",

pages = "533--545",

number = "4",

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Jimenez-Gomez, Y, Mattison, JA, Pearson, KJ, Martin-Montalvo, A, Palacios, HH, Sossong, AM, Ward, TM, Younts, CM, Lewis, K, Allard, JS, Longo, DL, Belman, JP, Malagon, MM, Navas, P, Sanghvi, M, Moaddel, R, Tilmont, EM, Herbert, RL, Morrell, CH, Egan, JM, Baur, JA, Ferrucci, L, Bogan, JS, Bernier, M & De Cabo, R 2013, 'Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet', Cell Metabolism, vol. 18, no. 4, pp. 533-545. https://doi.org/10.1016/j.cmet.2013.09.004

TY - JOUR

T1 - Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet

AU - Jimenez-Gomez, Yolanda

AU - Mattison, Julie A.

AU - Pearson, Kevin J.

AU - Martin-Montalvo, Alejandro

AU - Palacios, Hector H.

AU - Sossong, Alex M.

AU - Ward, Theresa M.

AU - Younts, Caitlin M.

AU - Lewis, Kaitlyn

AU - Allard, Joanne S.

AU - Longo, Dan L.

AU - Belman, Jonathan P.

AU - Malagon, Maria M.

AU - Navas, Placido

AU - Sanghvi, Mitesh

AU - Moaddel, Ruin

AU - Tilmont, Edward M.

AU - Herbert, Richard L.

AU - Morrell, Christopher H.

AU - Egan, Josephine M.

AU - Baur, Joseph A.

AU - Ferrucci, Luigi

AU - Bogan, Jonathan S.

AU - Bernier, Michel

AU - De Cabo, Rafael

N1 - Funding Information: This work was funded by the Intramural Research Program of the National Institute on Aging, NIH; the Office of Dietary Supplements, NIH; and by the NIH R01 DK075772 (to J.S.B.) and F30 DK093198 (to J.P.B.). Y.J.-G. was supported by a Sara Borrell fellowship of the Institute de Salud Carlos III (CD07/00208) and by a grant for actividades y estancias formativas of the Consejeria de Salud, Junta de Andalucia (EF-0122/2010), Spain. The authors would like to thank DSM Nutritional Products for providing the resveratrol (resVida). None of the authors have any conflict of interest that could affect the performance of the work or the interpretation of the data.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - SUMMARY Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with antiinflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.

AB - SUMMARY Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with antiinflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.

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UR - http://www.scopus.com/inward/citedby.url?scp=84885148256&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2013.09.004

DO - 10.1016/j.cmet.2013.09.004

M3 - Article

C2 - 24093677

AN - SCOPUS:84885148256

SN - 1550-4131

VL - 18

SP - 533

EP - 545

JO - Cell Metabolism

JF - Cell Metabolism

IS - 4

ER -

Resveratrol improves adipose insulin signaling and reducestheinflammatoryresponsein adiposetissue of rhesus monkeys on high-fat, high-sugar diet

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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