Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates

Julie A. Mattison; Mingyi Wang; Michel Bernier; Jing Zhang; Sung Soo Park; Stuart Maudsley; Steven S. An; Lakshmi Santhanam; Bronwen Martin; Shakeela Faulkner; Christopher Morrell; Joseph A. Baur; Leonid Peshkin; Danuta Sosnowska; Anna Csiszar; Richard L. Herbert; Edward M. Tilmont; Zoltan Ungvari; Kevin J. Pearson; Edward G. Lakatta; Rafael De Cabo

doi:10.1016/j.cmet.2014.04.018

Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates

Julie A. Mattison, Mingyi Wang, Michel Bernier, Jing Zhang, Sung Soo Park, Stuart Maudsley, Steven S. An, Lakshmi Santhanam, Bronwen Martin, Shakeela Faulkner, Christopher Morrell, Joseph A. Baur, Leonid Peshkin, Danuta Sosnowska, Anna Csiszar, Richard L. Herbert, Edward M. Tilmont, Zoltan Ungvari, Kevin J. Pearson, Edward G. LakattaRafael De Cabo

Research output: Contribution to journal › Article › peer-review

185 Scopus citations

Abstract

Central arterial wall stiffening, driven by a chronic inflammatory milieu, accompanies arterial diseases, the leading cause of cardiovascular (CV) morbidity and mortality in Western society. An increase in central arterial wall stiffening, measured as an increase in aortic pulse wave velocity (PWV), is a major risk factor for clinical CV disease events. However, no specific therapies to reduce PWV are presently available. In rhesus monkeys, a 2 year diet high in fat and sucrose (HFS) increases not only body weight and cholesterol, but also induces prominent central arterial wall stiffening and increases PWV and inflammation. The observed loss of endothelial cell integrity, lipid and macrophage infiltration, and calcification of the arterial wall were driven by genomic and proteomic signatures of oxidative stress and inflammation. Resveratrol prevented the HFS-induced arterial wall inflammation and the accompanying increase in PWV. Dietary resveratrol may hold promise as a therapy to ameliorate increases in PWV.

Original language	English
Pages (from-to)	183-190
Number of pages	8
Journal	Cell Metabolism
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2014.04.018
State	Published - Jul 1 2014

Bibliographical note

Funding Information:
We thank the animal care staff and technicians at the National Institute of Health Animal Center (NIHAC), in particular Joe Travis, as well as William Woods III, Elin Lehrmann, Yongqing Zhang, and Kevin G. Becker for microarray analysis. This research was supported by the Intramural Research Program of the NIH, National Institute on Aging, and the Office of Dietary Supplements, NIH. S.S.A. was the recipient of a National Heart, Lung, and Blood Institute grant HL107361. J.A.B. is a New Scholar of the Ellison Medical Foundation. Z.U. was supported by NIH/National Center for Complementary and Alternative Medicine (NCCAM) (AT006526). The resveratrol used in this study was a generous gift from DSM Nutritional Products (resVida).

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2014.04.018

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Mattison, J. A., Wang, M., Bernier, M., Zhang, J., Park, S. S., Maudsley, S., An, S. S., Santhanam, L., Martin, B., Faulkner, S., Morrell, C., Baur, J. A., Peshkin, L., Sosnowska, D., Csiszar, A., Herbert, R. L., Tilmont, E. M., Ungvari, Z., Pearson, K. J., ... De Cabo, R. (2014). Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. Cell Metabolism, 20(1), 183-190. https://doi.org/10.1016/j.cmet.2014.04.018

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title = "Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates",

abstract = "Central arterial wall stiffening, driven by a chronic inflammatory milieu, accompanies arterial diseases, the leading cause of cardiovascular (CV) morbidity and mortality in Western society. An increase in central arterial wall stiffening, measured as an increase in aortic pulse wave velocity (PWV), is a major risk factor for clinical CV disease events. However, no specific therapies to reduce PWV are presently available. In rhesus monkeys, a 2 year diet high in fat and sucrose (HFS) increases not only body weight and cholesterol, but also induces prominent central arterial wall stiffening and increases PWV and inflammation. The observed loss of endothelial cell integrity, lipid and macrophage infiltration, and calcification of the arterial wall were driven by genomic and proteomic signatures of oxidative stress and inflammation. Resveratrol prevented the HFS-induced arterial wall inflammation and the accompanying increase in PWV. Dietary resveratrol may hold promise as a therapy to ameliorate increases in PWV.",

author = "Mattison, {Julie A.} and Mingyi Wang and Michel Bernier and Jing Zhang and Park, {Sung Soo} and Stuart Maudsley and An, {Steven S.} and Lakshmi Santhanam and Bronwen Martin and Shakeela Faulkner and Christopher Morrell and Baur, {Joseph A.} and Leonid Peshkin and Danuta Sosnowska and Anna Csiszar and Herbert, {Richard L.} and Tilmont, {Edward M.} and Zoltan Ungvari and Pearson, {Kevin J.} and Lakatta, {Edward G.} and {De Cabo}, Rafael",

note = "Funding Information: We thank the animal care staff and technicians at the National Institute of Health Animal Center (NIHAC), in particular Joe Travis, as well as William Woods III, Elin Lehrmann, Yongqing Zhang, and Kevin G. Becker for microarray analysis. This research was supported by the Intramural Research Program of the NIH, National Institute on Aging, and the Office of Dietary Supplements, NIH. S.S.A. was the recipient of a National Heart, Lung, and Blood Institute grant HL107361. J.A.B. is a New Scholar of the Ellison Medical Foundation. Z.U. was supported by NIH/National Center for Complementary and Alternative Medicine (NCCAM) (AT006526). The resveratrol used in this study was a generous gift from DSM Nutritional Products (resVida). ",

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Mattison, JA, Wang, M, Bernier, M, Zhang, J, Park, SS, Maudsley, S, An, SS, Santhanam, L, Martin, B, Faulkner, S, Morrell, C, Baur, JA, Peshkin, L, Sosnowska, D, Csiszar, A, Herbert, RL, Tilmont, EM, Ungvari, Z, Pearson, KJ, Lakatta, EG & De Cabo, R 2014, 'Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates', Cell Metabolism, vol. 20, no. 1, pp. 183-190. https://doi.org/10.1016/j.cmet.2014.04.018

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T1 - Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates

AU - Mattison, Julie A.

AU - Wang, Mingyi

AU - Bernier, Michel

AU - Zhang, Jing

AU - Park, Sung Soo

AU - Maudsley, Stuart

AU - An, Steven S.

AU - Santhanam, Lakshmi

AU - Martin, Bronwen

AU - Faulkner, Shakeela

AU - Morrell, Christopher

AU - Baur, Joseph A.

AU - Peshkin, Leonid

AU - Sosnowska, Danuta

AU - Csiszar, Anna

AU - Herbert, Richard L.

AU - Tilmont, Edward M.

AU - Ungvari, Zoltan

AU - Pearson, Kevin J.

AU - Lakatta, Edward G.

AU - De Cabo, Rafael

N1 - Funding Information: We thank the animal care staff and technicians at the National Institute of Health Animal Center (NIHAC), in particular Joe Travis, as well as William Woods III, Elin Lehrmann, Yongqing Zhang, and Kevin G. Becker for microarray analysis. This research was supported by the Intramural Research Program of the NIH, National Institute on Aging, and the Office of Dietary Supplements, NIH. S.S.A. was the recipient of a National Heart, Lung, and Blood Institute grant HL107361. J.A.B. is a New Scholar of the Ellison Medical Foundation. Z.U. was supported by NIH/National Center for Complementary and Alternative Medicine (NCCAM) (AT006526). The resveratrol used in this study was a generous gift from DSM Nutritional Products (resVida).

PY - 2014/7/1

Y1 - 2014/7/1

N2 - Central arterial wall stiffening, driven by a chronic inflammatory milieu, accompanies arterial diseases, the leading cause of cardiovascular (CV) morbidity and mortality in Western society. An increase in central arterial wall stiffening, measured as an increase in aortic pulse wave velocity (PWV), is a major risk factor for clinical CV disease events. However, no specific therapies to reduce PWV are presently available. In rhesus monkeys, a 2 year diet high in fat and sucrose (HFS) increases not only body weight and cholesterol, but also induces prominent central arterial wall stiffening and increases PWV and inflammation. The observed loss of endothelial cell integrity, lipid and macrophage infiltration, and calcification of the arterial wall were driven by genomic and proteomic signatures of oxidative stress and inflammation. Resveratrol prevented the HFS-induced arterial wall inflammation and the accompanying increase in PWV. Dietary resveratrol may hold promise as a therapy to ameliorate increases in PWV.

AB - Central arterial wall stiffening, driven by a chronic inflammatory milieu, accompanies arterial diseases, the leading cause of cardiovascular (CV) morbidity and mortality in Western society. An increase in central arterial wall stiffening, measured as an increase in aortic pulse wave velocity (PWV), is a major risk factor for clinical CV disease events. However, no specific therapies to reduce PWV are presently available. In rhesus monkeys, a 2 year diet high in fat and sucrose (HFS) increases not only body weight and cholesterol, but also induces prominent central arterial wall stiffening and increases PWV and inflammation. The observed loss of endothelial cell integrity, lipid and macrophage infiltration, and calcification of the arterial wall were driven by genomic and proteomic signatures of oxidative stress and inflammation. Resveratrol prevented the HFS-induced arterial wall inflammation and the accompanying increase in PWV. Dietary resveratrol may hold promise as a therapy to ameliorate increases in PWV.

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Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates

Abstract

Bibliographical note

ASJC Scopus subject areas

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