Central arterial wall stiffening, driven by a chronic inflammatory milieu, accompanies arterial diseases, the leading cause of cardiovascular (CV) morbidity and mortality in Western society. An increase in central arterial wall stiffening, measured as an increase in aortic pulse wave velocity (PWV), is a major risk factor for clinical CV disease events. However, no specific therapies to reduce PWV are presently available. In rhesus monkeys, a 2 year diet high in fat and sucrose (HFS) increases not only body weight and cholesterol, but also induces prominent central arterial wall stiffening and increases PWV and inflammation. The observed loss of endothelial cell integrity, lipid and macrophage infiltration, and calcification of the arterial wall were driven by genomic and proteomic signatures of oxidative stress and inflammation. Resveratrol prevented the HFS-induced arterial wall inflammation and the accompanying increase in PWV. Dietary resveratrol may hold promise as a therapy to ameliorate increases in PWV.
|Number of pages||8|
|State||Published - Jul 1 2014|
Bibliographical noteFunding Information:
We thank the animal care staff and technicians at the National Institute of Health Animal Center (NIHAC), in particular Joe Travis, as well as William Woods III, Elin Lehrmann, Yongqing Zhang, and Kevin G. Becker for microarray analysis. This research was supported by the Intramural Research Program of the NIH, National Institute on Aging, and the Office of Dietary Supplements, NIH. S.S.A. was the recipient of a National Heart, Lung, and Blood Institute grant HL107361. J.A.B. is a New Scholar of the Ellison Medical Foundation. Z.U. was supported by NIH/National Center for Complementary and Alternative Medicine (NCCAM) (AT006526). The resveratrol used in this study was a generous gift from DSM Nutritional Products (resVida).
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology