Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses

Stephen S. Leonard; Chang Xia; Bin Hua Jiang; Beth Stinefelt; Hillar Klandorf; Gabriel K. Harris; Xianglin Shi

doi:10.1016/j.bbrc.2003.08.105

Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses

Stephen S. Leonard, Chang Xia, Bin Hua Jiang, Beth Stinefelt, Hillar Klandorf, Gabriel K. Harris, Xianglin Shi

Toxicology and Cancer Biology

Research output: Contribution to journal › Article › peer-review

620 Scopus citations

Abstract

Scavenging or quenching of the reactive oxygen species (ROS) involved in oxidative stress has been the subject of many recent studies. Resveratrol, found in various natural food products, has been linked to decreased coronary artery disease and preventing cancer development. The present study measured the effect of resveratrol on several different systems involving the hydroxyl, superoxide, metal/enzymatic-induced, and cellular generated radicals. The rate constant for reaction of resveratrol with the hydroxyl radical was determined, and resveratrol was found to be an effective scavenger of hydroxyl, superoxide, and metal-induced radicals as well as showing antioxidant abilities in cells producing ROS. Resveratrol exhibits a protective effect against lipid peroxidation in cell membranes and DNA damage caused by ROS. Resveratrol was also found to have a significant inhibitory effect on the NF-κB signaling pathway after cellular exposure to metal-induced radicals. It was concluded that resveratrol in foods plays an important antioxidant role.

Original language	English
Pages (from-to)	1017-1026
Number of pages	10
Journal	Biochemical and Biophysical Research Communications
Volume	309
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2003.08.105
State	Published - Oct 3 2003

Bibliographical note

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

Cr(VI)
DNA damage
Hydroxyl radicals
Lipid peroxidation
NF-κB activation
Resveratrol
Superoxide radicals

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2003.08.105

Cite this

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title = "Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses",

abstract = "Scavenging or quenching of the reactive oxygen species (ROS) involved in oxidative stress has been the subject of many recent studies. Resveratrol, found in various natural food products, has been linked to decreased coronary artery disease and preventing cancer development. The present study measured the effect of resveratrol on several different systems involving the hydroxyl, superoxide, metal/enzymatic-induced, and cellular generated radicals. The rate constant for reaction of resveratrol with the hydroxyl radical was determined, and resveratrol was found to be an effective scavenger of hydroxyl, superoxide, and metal-induced radicals as well as showing antioxidant abilities in cells producing ROS. Resveratrol exhibits a protective effect against lipid peroxidation in cell membranes and DNA damage caused by ROS. Resveratrol was also found to have a significant inhibitory effect on the NF-κB signaling pathway after cellular exposure to metal-induced radicals. It was concluded that resveratrol in foods plays an important antioxidant role.",

keywords = "Cr(VI), DNA damage, Hydroxyl radicals, Lipid peroxidation, NF-κB activation, Resveratrol, Superoxide radicals",

author = "Leonard, {Stephen S.} and Chang Xia and Jiang, {Bin Hua} and Beth Stinefelt and Hillar Klandorf and Harris, {Gabriel K.} and Xianglin Shi",

year = "2003",

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doi = "10.1016/j.bbrc.2003.08.105",

language = "English",

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AU - Leonard, Stephen S.

AU - Xia, Chang

AU - Jiang, Bin Hua

AU - Stinefelt, Beth

AU - Klandorf, Hillar

AU - Harris, Gabriel K.

AU - Shi, Xianglin

PY - 2003/10/3

Y1 - 2003/10/3

N2 - Scavenging or quenching of the reactive oxygen species (ROS) involved in oxidative stress has been the subject of many recent studies. Resveratrol, found in various natural food products, has been linked to decreased coronary artery disease and preventing cancer development. The present study measured the effect of resveratrol on several different systems involving the hydroxyl, superoxide, metal/enzymatic-induced, and cellular generated radicals. The rate constant for reaction of resveratrol with the hydroxyl radical was determined, and resveratrol was found to be an effective scavenger of hydroxyl, superoxide, and metal-induced radicals as well as showing antioxidant abilities in cells producing ROS. Resveratrol exhibits a protective effect against lipid peroxidation in cell membranes and DNA damage caused by ROS. Resveratrol was also found to have a significant inhibitory effect on the NF-κB signaling pathway after cellular exposure to metal-induced radicals. It was concluded that resveratrol in foods plays an important antioxidant role.

AB - Scavenging or quenching of the reactive oxygen species (ROS) involved in oxidative stress has been the subject of many recent studies. Resveratrol, found in various natural food products, has been linked to decreased coronary artery disease and preventing cancer development. The present study measured the effect of resveratrol on several different systems involving the hydroxyl, superoxide, metal/enzymatic-induced, and cellular generated radicals. The rate constant for reaction of resveratrol with the hydroxyl radical was determined, and resveratrol was found to be an effective scavenger of hydroxyl, superoxide, and metal-induced radicals as well as showing antioxidant abilities in cells producing ROS. Resveratrol exhibits a protective effect against lipid peroxidation in cell membranes and DNA damage caused by ROS. Resveratrol was also found to have a significant inhibitory effect on the NF-κB signaling pathway after cellular exposure to metal-induced radicals. It was concluded that resveratrol in foods plays an important antioxidant role.

KW - Cr(VI)

KW - DNA damage

KW - Hydroxyl radicals

KW - Lipid peroxidation

KW - NF-κB activation

KW - Resveratrol

KW - Superoxide radicals

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M3 - Article

C2 - 13679076

AN - SCOPUS:0141788133

SN - 0006-291X

VL - 309

SP - 1017

EP - 1026

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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