Reticuloendothelial clearance and splenic mononuclear cell populations after resection and autotransplantation

Mark A. Malangoni, B. Mark Evers, James C. Peyton, Samuel R. Wellhausen

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Although the preservation of splenic tissue may prevent overwhelming infection after splenectomy, the degree of protection conferred by small remnants has not been optimal. We investigated whether either splenic reticuloendothelial clearance of a blood flow-dependent colloid or macrophage and T-cell populations might be altered by resection or autotransplantation of the spleen. Our results have shown that bloodstream reticuloendothelial clearance of technetium 99m sulfur colloid is not impaired by splenectomy, partial resection of the spleen, or splenic autotransplantation. Such clearance is dependent on spleen weight and is not related to differences in either macrophage or helper or suppressor T-cell populations. This suggests that autotransplantation of the spleen is inferior to preservation of even a small hilar remnant and implies that repair or partial resection of the spleen will provide greater protection than autotransplantation.

Original languageEnglish
Pages (from-to)298-302
Number of pages5
JournalAmerican Journal of Surgery
Issue number2
StatePublished - Feb 1988

Bibliographical note

Funding Information:
From the Department of Surgery, the Division of Nephrology, and the Department of Medicine, University of LouisVille School of Medicine, Louisville, Kentucky. Supported in part by the Veterans Administration, Washington, DC.

ASJC Scopus subject areas

  • Surgery


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