REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American

Marta Garaulet, Caren E. Smith, Purificación Gomez-Abellán, María Ordovás-Montañés, Yu Chi Lee, Laurence D. Parnell, Donna K. Arnett, José M. Ordovás

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Scope: Despite the solid connection between REV-ERB and obesity, the information about whether genetic variations at this locus may be associated with obesity traits is scarce. Therefore our objective was to study the association between REV-ERB-ALPHA1 rs2314339 and obesity in two independent populations. Methods and results: Participants were 2214 subjects from Spanish Mediterranean (n = 1404) and North American (n = 810) populations. Anthropometric, biochemical, dietary, and genotype analyses were performed. We found novel associations between the REV-ERB-ALPHA1 rs2314339 genotype and obesity in two independent populations: in Spanish Mediterranean and North American groups, the frequency of the minor-allele-carriers (AA+ AG) was significantly lower in the "abdominally obese" group than in those of the "nonabdominally obese" group (p < 0.05). Minor allele carriers had lower probability of abdominal obesity than noncarriers, and the effect was of similar magnitude for both populations (OR ≈ 1.50). There were consistent associations between REV-ERB-ALPHA1 genotype and obesity-related traits (p < 0.05). Energy intake was not significantly associated with REV-ERB-ALPHA1 rs2314339. However, physical activity significantly differed by genotype. A significant interaction between the REV-ERB-ALPHA1 variant and monounsaturated-fatty-acids (MUFA) intake for obesity was also detected in the Mediterranean population. Conclusion: This new discovery highlights the importance of REV-ERB-ALPHA1 in obesity and provides evidence for the connection between our biological clock and obesity-related traits.

Original languageEnglish
Pages (from-to)821-829
Number of pages9
JournalMolecular Nutrition and Food Research
Issue number4
StatePublished - Apr 2014


  • Circadian
  • Clock genes
  • Obesity
  • Single nucleotide Polymorphism

ASJC Scopus subject areas

  • Biotechnology
  • Food Science


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