Abstract
Genetic manipulation that reduces the competence of a vector population to transmit pathogens would provide a useful tool to complement current control strategies, which are based primarily on the reduction/exclusion of vector populations and the prophylactic/therapeutic treatment of the vertebrate host population. Genetic drive is an important component of vector population replacement strategies, facilitating the replacement of natural populations with a genetically modified population. Genetic drive is reviewed here, emphasizing strategies that would employ infections of intracellular Wolbachia bacteria as a vehicle for population replacement. Also discussed are strategies for the retarding, arresting or reversing of Wolbachia-based population replacement. These strategies are based upon altering the conditions required for transgene invasion and are a prudent safeguard, should unexpected detrimental effects become associated with transgene spread.
| Original language | English |
|---|---|
| Pages (from-to) | 128-133 |
| Number of pages | 6 |
| Journal | Trends in Parasitology |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2003 |
Bibliographical note
Funding Information:This research was supported in part by the United States Department of Agriculture NRICGP grant #9902683. This is publication 02-08-188 of the University of Kentucky Agricultural Experiment Station.
ASJC Scopus subject areas
- Parasitology
- Infectious Diseases
