Reversing Wolbachia-based population replacement

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations


Genetic manipulation that reduces the competence of a vector population to transmit pathogens would provide a useful tool to complement current control strategies, which are based primarily on the reduction/exclusion of vector populations and the prophylactic/therapeutic treatment of the vertebrate host population. Genetic drive is an important component of vector population replacement strategies, facilitating the replacement of natural populations with a genetically modified population. Genetic drive is reviewed here, emphasizing strategies that would employ infections of intracellular Wolbachia bacteria as a vehicle for population replacement. Also discussed are strategies for the retarding, arresting or reversing of Wolbachia-based population replacement. These strategies are based upon altering the conditions required for transgene invasion and are a prudent safeguard, should unexpected detrimental effects become associated with transgene spread.

Original languageEnglish
Pages (from-to)128-133
Number of pages6
JournalTrends in Parasitology
Issue number3
StatePublished - Mar 1 2003

Bibliographical note

Funding Information:
This research was supported in part by the United States Department of Agriculture NRICGP grant #9902683. This is publication 02-08-188 of the University of Kentucky Agricultural Experiment Station.

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases


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