Review: Mechanisms underlying alternative polyadenylation in plants – looking in the right places

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Recent years have seen an explosion of interest in the subject of alternative polyadenylation in plants. Connections between the polyadenylation complex and numerous developmental and stress responses are well-established. However, those that link stimuli with the functioning of the polyadenylation complex are less well understood. To this end, it is imperative to clearly delineate the roles of the polyadenylation complex in both plant growth AND alternative polyadenylation. It is also necessary to understand the ways by which other molecular processes may contribute to alternative polyadenylation. This review discusses these issues, with a focus on instances that reveal mechanisms by which mRNA polyadenylation may be regulated. Insights from from characterizations of mutants affected in the polyadenylation complex are discussed, as are the limitations of such characterizations when it comes to teasing out cause and effect. These limitations encourage explorations to other processes that are beyond the core polyadenylation complex. Two such processes that sculpt the plant transcriptome – transcription termination and the epigenetic control of transposon activity – also contribute to regulated poly(A) site choice. These subjects define “the right places” – molecular mechanisms that contribute to the wide-ranging control of gene expression via mRNA polyadenylation.

Original languageEnglish
Article number111430
JournalPlant Science
Volume324
DOIs
StatePublished - Nov 2022

Bibliographical note

Funding Information:
The author thanks comments and suggestions made by the reviewers. The author’s research has supported by the National Science Foundation (awards 1353354 and 1243849), the USDA Agricultural Research Service (Co-operative Agreement No. 58-5042-8-003 ), and the University of Kentucky .

Publisher Copyright:
© 2022

Keywords

  • Alternative polyadenylation
  • Epigenetic control
  • Gene regulation

ASJC Scopus subject areas

  • Genetics
  • Agronomy and Crop Science
  • Plant Science

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