TY - JOUR
T1 - Review of Integrin-Targeting Biomaterials in Tissue Engineering
AU - Dhavalikar, Prachi
AU - Robinson, Andrew
AU - Lan, Ziyang
AU - Jenkins, Dana
AU - Chwatko, Malgorzata
AU - Salhadar, Karim
AU - Jose, Anupriya
AU - Kar, Ronit
AU - Shoga, Erik
AU - Kannapiran, Aparajith
AU - Cosgriff-Hernandez, Elizabeth
N1 - Publisher Copyright:
© 2020 Wiley-VCH GmbH
PY - 2020/12/2
Y1 - 2020/12/2
N2 - The ability to direct cell behavior has been central to the success of numerous therapeutics to regenerate tissue or facilitate device integration. Biomaterial scientists are challenged to understand and modulate the interactions of biomaterials with biological systems in order to achieve effective tissue repair. One key area of research investigates the use of extracellular matrix-derived ligands to target specific integrin interactions and induce cellular responses, such as increased cell migration, proliferation, and differentiation of mesenchymal stem cells. These integrin-targeting proteins and peptides have been implemented in a variety of different polymeric scaffolds and devices to enhance tissue regeneration and integration. This review first presents an overview of integrin-mediated cellular processes that have been identified in angiogenesis, wound healing, and bone regeneration. Then, research utilizing biomaterials are highlighted with integrin-targeting motifs as a means to direct these cellular processes to enhance tissue regeneration. In addition to providing improved materials for tissue repair and device integration, these innovative biomaterials provide new tools to probe the complex processes of tissue remodeling in order to enhance the rational design of biomaterial scaffolds and guide tissue regeneration strategies.
AB - The ability to direct cell behavior has been central to the success of numerous therapeutics to regenerate tissue or facilitate device integration. Biomaterial scientists are challenged to understand and modulate the interactions of biomaterials with biological systems in order to achieve effective tissue repair. One key area of research investigates the use of extracellular matrix-derived ligands to target specific integrin interactions and induce cellular responses, such as increased cell migration, proliferation, and differentiation of mesenchymal stem cells. These integrin-targeting proteins and peptides have been implemented in a variety of different polymeric scaffolds and devices to enhance tissue regeneration and integration. This review first presents an overview of integrin-mediated cellular processes that have been identified in angiogenesis, wound healing, and bone regeneration. Then, research utilizing biomaterials are highlighted with integrin-targeting motifs as a means to direct these cellular processes to enhance tissue regeneration. In addition to providing improved materials for tissue repair and device integration, these innovative biomaterials provide new tools to probe the complex processes of tissue remodeling in order to enhance the rational design of biomaterial scaffolds and guide tissue regeneration strategies.
KW - angiogenesis
KW - biomaterials
KW - bone regeneration
KW - integrins
KW - wound healing
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U2 - 10.1002/adhm.202000795
DO - 10.1002/adhm.202000795
M3 - Review article
C2 - 32940020
AN - SCOPUS:85090983810
SN - 2192-2640
VL - 9
JO - Advanced healthcare materials
JF - Advanced healthcare materials
IS - 23
M1 - 2000795
ER -