Review of Integrin-Targeting Biomaterials in Tissue Engineering

Prachi Dhavalikar, Andrew Robinson, Ziyang Lan, Dana Jenkins, Malgorzata Chwatko, Karim Salhadar, Anupriya Jose, Ronit Kar, Erik Shoga, Aparajith Kannapiran, Elizabeth Cosgriff-Hernandez

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

The ability to direct cell behavior has been central to the success of numerous therapeutics to regenerate tissue or facilitate device integration. Biomaterial scientists are challenged to understand and modulate the interactions of biomaterials with biological systems in order to achieve effective tissue repair. One key area of research investigates the use of extracellular matrix-derived ligands to target specific integrin interactions and induce cellular responses, such as increased cell migration, proliferation, and differentiation of mesenchymal stem cells. These integrin-targeting proteins and peptides have been implemented in a variety of different polymeric scaffolds and devices to enhance tissue regeneration and integration. This review first presents an overview of integrin-mediated cellular processes that have been identified in angiogenesis, wound healing, and bone regeneration. Then, research utilizing biomaterials are highlighted with integrin-targeting motifs as a means to direct these cellular processes to enhance tissue regeneration. In addition to providing improved materials for tissue repair and device integration, these innovative biomaterials provide new tools to probe the complex processes of tissue remodeling in order to enhance the rational design of biomaterial scaffolds and guide tissue regeneration strategies.

Original languageEnglish
Article number2000795
JournalAdvanced healthcare materials
Volume9
Issue number23
DOIs
StatePublished - Dec 2 2020

Bibliographical note

Funding Information:
Funding was provided by the National Science Foundation, Grant No. 1822196, and National Institutes of Health, Grant No. R21AR076107.

Publisher Copyright:
© 2020 Wiley-VCH GmbH

Keywords

  • angiogenesis
  • biomaterials
  • bone regeneration
  • integrins
  • wound healing

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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