Review of oral oxymorphone in the management of pain

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Chronic cancer and nonmalignant pain (CNMP) is a common and major health problem afflicting approximately 40 million persons in the US. Most cancer patients, and many patients with CNMP, require opioid analgesics to obtain adequate pain relief. Oral oxymorpbone is a new formulation of an existing parenteral opioid that has become available for the treatment of significant pain: acute postoperative, chronic arthritis, chronic low back, and chronic cancer pain. Oxymorphone is a typical mu-opioid agonist that is effective in both immediate- and extended-release (IR and ER) formulations. Oxymorphone is more lipid soluble than morphine, resulting in a rapid onset of action when given in tablet formulation, with a duration of action of approximately 4-6 hours in IR and 12 hours in ER preparations. Oxymorphone provides excellent pain relief for significant pain, with typical opioid side effects that are usually mild or moderate in intensity. Multiple double-blind, prospective, placebo-controlled clinical trials have demonstrated the clinical efficacy and safety of this new oral opioid preparation. Oral oxymorphone is an effective opioid that provides a new therapeutic option for the physician.

Original languageEnglish
Pages (from-to)777-787
Number of pages11
JournalTherapeutics and Clinical Risk Management
Volume4
Issue number4
StatePublished - 2008

Keywords

  • Cancer pain
  • Chronic pain
  • Extended-release
  • Opioids
  • Oxymorphone
  • Sustained-release

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • Pharmacology (medical)
  • Chemical Health and Safety
  • Safety Research

Fingerprint

Dive into the research topics of 'Review of oral oxymorphone in the management of pain'. Together they form a unique fingerprint.

Cite this