Revisiting optimal anticoagulation with unfractionated heparin during coronary stent implantation

Sorin J. Brener; Deepak L. Bhatt; David J. Moliterno; Jakob P. Schneider; Stephen G. Ellis; Eric J. Topol

doi:10.1016/j.amjcard.2003.08.063

Revisiting optimal anticoagulation with unfractionated heparin during coronary stent implantation

Sorin J. Brener, Deepak L. Bhatt, David J. Moliterno, Jakob P. Schneider, Stephen G. Ellis, Eric J. Topol

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Using univariate and multivariate analyses, we evaluated the relation between ischemic and bleeding complications and peak procedural activated clotting time (ACT) in patients undergoing percutaneous coronary intervention whose coronary narrowings were treated with stent implantation. Of the 2,280 patients who qualified for the study, 29% had diabetes mellitus, and 91% received glycoprotein IIb/IIIa inhibitors. The median for ACT was 276 seconds (interquartile range 243 to 317). The incidence of ischemic events by ACT quartiles was 6.3%, 7.5%, 8.1%, and 7.1%, respectively (p = 0.71). The incidence of bleeding complications was 6.6%, 5.9%, 6.9%, and 7.3%, respectively (p = 0.81). ACT did not independently predict either ischemic or hemorrhagic complications.

Original language	English
Pages (from-to)	1468-1471
Number of pages	4
Journal	American Journal of Cardiology
Volume	92
Issue number	12
DOIs	https://doi.org/10.1016/j.amjcard.2003.08.063
State	Published - Dec 15 2003

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.amjcard.2003.08.063

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title = "Revisiting optimal anticoagulation with unfractionated heparin during coronary stent implantation",

abstract = "Using univariate and multivariate analyses, we evaluated the relation between ischemic and bleeding complications and peak procedural activated clotting time (ACT) in patients undergoing percutaneous coronary intervention whose coronary narrowings were treated with stent implantation. Of the 2,280 patients who qualified for the study, 29% had diabetes mellitus, and 91% received glycoprotein IIb/IIIa inhibitors. The median for ACT was 276 seconds (interquartile range 243 to 317). The incidence of ischemic events by ACT quartiles was 6.3%, 7.5%, 8.1%, and 7.1%, respectively (p = 0.71). The incidence of bleeding complications was 6.6%, 5.9%, 6.9%, and 7.3%, respectively (p = 0.81). ACT did not independently predict either ischemic or hemorrhagic complications.",

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AU - Brener, Sorin J.

AU - Bhatt, Deepak L.

AU - Moliterno, David J.

AU - Schneider, Jakob P.

AU - Ellis, Stephen G.

AU - Topol, Eric J.

PY - 2003/12/15

Y1 - 2003/12/15

N2 - Using univariate and multivariate analyses, we evaluated the relation between ischemic and bleeding complications and peak procedural activated clotting time (ACT) in patients undergoing percutaneous coronary intervention whose coronary narrowings were treated with stent implantation. Of the 2,280 patients who qualified for the study, 29% had diabetes mellitus, and 91% received glycoprotein IIb/IIIa inhibitors. The median for ACT was 276 seconds (interquartile range 243 to 317). The incidence of ischemic events by ACT quartiles was 6.3%, 7.5%, 8.1%, and 7.1%, respectively (p = 0.71). The incidence of bleeding complications was 6.6%, 5.9%, 6.9%, and 7.3%, respectively (p = 0.81). ACT did not independently predict either ischemic or hemorrhagic complications.

AB - Using univariate and multivariate analyses, we evaluated the relation between ischemic and bleeding complications and peak procedural activated clotting time (ACT) in patients undergoing percutaneous coronary intervention whose coronary narrowings were treated with stent implantation. Of the 2,280 patients who qualified for the study, 29% had diabetes mellitus, and 91% received glycoprotein IIb/IIIa inhibitors. The median for ACT was 276 seconds (interquartile range 243 to 317). The incidence of ischemic events by ACT quartiles was 6.3%, 7.5%, 8.1%, and 7.1%, respectively (p = 0.71). The incidence of bleeding complications was 6.6%, 5.9%, 6.9%, and 7.3%, respectively (p = 0.81). ACT did not independently predict either ischemic or hemorrhagic complications.

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Revisiting optimal anticoagulation with unfractionated heparin during coronary stent implantation

Abstract

ASJC Scopus subject areas

UN SDGs

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