TY - JOUR
T1 - Rheumatoid meningitis
AU - Qin, Zhaoyi
AU - Kim, June
AU - Valencia, Damian
AU - Hamoodi, Lames
AU - Neltner, Jenna
AU - Sizemore, Travis
AU - Lightfoot, Robert
N1 - Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Purpose of review Rheumatoid arthritis is a systemic inflammatory disorder, which can involve many organs; among which, CNS involvement, as in rheumatoid meningitis (RM), is rare and difficult to recognize. Our goal is to present collective data of RM cases to better characterize this disease process and to start new discussions about pathophysiology, diagnosis, and treatment. Recent findings Since Kato et al., 39 cases of RM have been reported. Approximately 59% were women, presenting with neurologic deficits (56%) and diagnosed by MRI findings, leptomeningeal enhancement (69%), after CSF analysis. Seventy-four percent were treated with corticosteroids, 64% as maintenance therapy, with 46% experiencing improvement or resolution in symptoms without relapse. Summary Diagnosis and prognosis of RM has drastically changed since the year 2000. Early detection with CSF and MRI or biopsy findings, coupled with early treatment using corticosteroids and immunologic therapy, has reduced mortality in this population.
AB - Purpose of review Rheumatoid arthritis is a systemic inflammatory disorder, which can involve many organs; among which, CNS involvement, as in rheumatoid meningitis (RM), is rare and difficult to recognize. Our goal is to present collective data of RM cases to better characterize this disease process and to start new discussions about pathophysiology, diagnosis, and treatment. Recent findings Since Kato et al., 39 cases of RM have been reported. Approximately 59% were women, presenting with neurologic deficits (56%) and diagnosed by MRI findings, leptomeningeal enhancement (69%), after CSF analysis. Seventy-four percent were treated with corticosteroids, 64% as maintenance therapy, with 46% experiencing improvement or resolution in symptoms without relapse. Summary Diagnosis and prognosis of RM has drastically changed since the year 2000. Early detection with CSF and MRI or biopsy findings, coupled with early treatment using corticosteroids and immunologic therapy, has reduced mortality in this population.
UR - https://www.scopus.com/pages/publications/85161590677
UR - https://www.scopus.com/inward/citedby.url?scp=85161590677&partnerID=8YFLogxK
U2 - 10.1212/CPJ.0000000000000678
DO - 10.1212/CPJ.0000000000000678
M3 - Review article
AN - SCOPUS:85161590677
SN - 2163-0402
VL - 10
SP - 73
EP - 83
JO - Neurology: Clinical Practice
JF - Neurology: Clinical Practice
IS - 1
ER -