Ribonuclease activity is a common property of Arabidopsis CCCH-containing zinc-finger proteins

Balasubrahmanyam Addepalli, Arthur G. Hunt

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The CCCH class of zinc fingers occurs in a large number of Arabidopsis proteins. Previous studies revealed that one such protein is a nuclease, the activity of which is attributable to one of the CCCH motifs. To examine whether nuclease activity is a more general characteristic of CCCH zinc finger containing proteins, five other such Arabidopsis proteins were assayed for a similar activity. The results indicate that all of these proteins possess nuclease activity. Thus, nuclease activity may be a common characteristic of Arabidopsis CCCH-containing proteins.

Original languageEnglish
Pages (from-to)2577-2582
Number of pages6
JournalFEBS Letters
Volume582
Issue number17
DOIs
StatePublished - Jul 23 2008

Bibliographical note

Funding Information:
The authors thank Carol Von Lanken for excellent technical and administrative support. This work was supported by NSF Arabidopsis 2010 Grant MCB-0313472.

Keywords

  • Polyadenylation
  • RNA binding
  • Ribonuclease
  • Zinc-finger protein

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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