Ribonuclease activity is a common property of Arabidopsis CCCH-containing zinc-finger proteins

Balasubrahmanyam Addepalli; Arthur G. Hunt

doi:10.1016/j.febslet.2008.06.029

Ribonuclease activity is a common property of Arabidopsis CCCH-containing zinc-finger proteins

Balasubrahmanyam Addepalli, Arthur G. Hunt

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32 Scopus citations

Abstract

The CCCH class of zinc fingers occurs in a large number of Arabidopsis proteins. Previous studies revealed that one such protein is a nuclease, the activity of which is attributable to one of the CCCH motifs. To examine whether nuclease activity is a more general characteristic of CCCH zinc finger containing proteins, five other such Arabidopsis proteins were assayed for a similar activity. The results indicate that all of these proteins possess nuclease activity. Thus, nuclease activity may be a common characteristic of Arabidopsis CCCH-containing proteins.

Original language	English
Pages (from-to)	2577-2582
Number of pages	6
Journal	FEBS Letters
Volume	582
Issue number	17
DOIs	https://doi.org/10.1016/j.febslet.2008.06.029
State	Published - Jul 23 2008

Bibliographical note

Funding Information:
The authors thank Carol Von Lanken for excellent technical and administrative support. This work was supported by NSF Arabidopsis 2010 Grant MCB-0313472.

Keywords

Polyadenylation
RNA binding
Ribonuclease
Zinc-finger protein

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2008.06.029

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title = "Ribonuclease activity is a common property of Arabidopsis CCCH-containing zinc-finger proteins",

abstract = "The CCCH class of zinc fingers occurs in a large number of Arabidopsis proteins. Previous studies revealed that one such protein is a nuclease, the activity of which is attributable to one of the CCCH motifs. To examine whether nuclease activity is a more general characteristic of CCCH zinc finger containing proteins, five other such Arabidopsis proteins were assayed for a similar activity. The results indicate that all of these proteins possess nuclease activity. Thus, nuclease activity may be a common characteristic of Arabidopsis CCCH-containing proteins.",

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AU - Addepalli, Balasubrahmanyam

AU - Hunt, Arthur G.

N1 - Funding Information: The authors thank Carol Von Lanken for excellent technical and administrative support. This work was supported by NSF Arabidopsis 2010 Grant MCB-0313472.

PY - 2008/7/23

Y1 - 2008/7/23

N2 - The CCCH class of zinc fingers occurs in a large number of Arabidopsis proteins. Previous studies revealed that one such protein is a nuclease, the activity of which is attributable to one of the CCCH motifs. To examine whether nuclease activity is a more general characteristic of CCCH zinc finger containing proteins, five other such Arabidopsis proteins were assayed for a similar activity. The results indicate that all of these proteins possess nuclease activity. Thus, nuclease activity may be a common characteristic of Arabidopsis CCCH-containing proteins.

AB - The CCCH class of zinc fingers occurs in a large number of Arabidopsis proteins. Previous studies revealed that one such protein is a nuclease, the activity of which is attributable to one of the CCCH motifs. To examine whether nuclease activity is a more general characteristic of CCCH zinc finger containing proteins, five other such Arabidopsis proteins were assayed for a similar activity. The results indicate that all of these proteins possess nuclease activity. Thus, nuclease activity may be a common characteristic of Arabidopsis CCCH-containing proteins.

KW - Polyadenylation

KW - RNA binding

KW - Ribonuclease

KW - Zinc-finger protein

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JO - FEBS Letters

JF - FEBS Letters

IS - 17

ER -

Ribonuclease activity is a common property of Arabidopsis CCCH-containing zinc-finger proteins

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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