Ribosome biogenesis is necessary for skeletal muscle hypertrophy

The results of studies from our laboratory, as well as other investigators in the field, have shown clearly that ribosome biogenesis is increased in response to RE, and that this response is conserved across species and affected in a similarmanner with aging. Moreover, there is a strong correlation between the level of ribosome biogenesis and the magnitude of hypertrophy that also is conserved in both humans and rodents. Although the findings of these studies collectively make a strong argument for the necessity of ribosome biogenesis in skeletal muscle hypertrophy, they remain descriptive in nature. The challenge for the field moving forward will be to carry out in vivo lossand gain-of-function experiments with components of the Pol I regulon and master regulators (such as c-Myc) to rigorously test the hypothesis that ribosome biogenesis is necessary for skeletal muscle hypertrophy. The results of such experiments are expected to show that both translational efficiency and capacity serve critical roles in the regulation of skeletal muscle hypertrophy.