Abstract
Background: 53BP1 counteracts BRCA1 in DNA repair. Results: RIF1 acts downstream of 53BP1 and counteracts BRCA1 in DNA end resection. It also has a 53BP1-independent role in regulating BLM chromatin association. Conclusion: RIF1 is the major downstream effector of 53BP1. Significance: These results reveal that RIF1 antagonizes BRCA1, functions in DNA end protection, and prevents homologous recombination repair.
Original language | English |
---|---|
Pages (from-to) | 11135-11143 |
Number of pages | 9 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 16 |
DOIs | |
State | Published - Apr 19 2013 |
Funding
Funders | Funder number |
---|---|
National Childhood Cancer Registry – National Cancer Institute | R01CA100109 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology