Right Ventricular Dyssynchrony in Heart Failure: A Tissue Doppler Imaging Study

Navin Rajagopalan, Kaoru Dohi, Marc A. Simon, Matthew Suffoletto, Kathy Edelman, Srinivas Murali, Angel López-Candales

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Background: The development of right ventricular dysfunction is a poor prognostic sign in patients with heart failure (HF). Although left ventricular dyssynchrony has been well described, it is not known whether right ventricular dyssynchrony coexists in HF. We used tissue Doppler imaging to determine whether right ventricular dyssynchrony is also present in HF patients. Methods and Results: In 34 HF patients (mean age 56 ± 13 years), we measured longitudinal strain at the right ventricular free wall, interventricular septum, and left ventricular lateral wall. Right ventricular and left ventricular dyssynchrony were defined as the difference in time to peak strain between the right ventricular free wall and the septum and between the left ventricular lateral wall and septum, respectively. Mean right ventricular dyssynchrony was 59 ± 45 ms and the mean left ventricular dyssynchrony was 80 ± 62 ms. We found a strong correlation between right ventricular dyssynchrony and pulmonary artery systolic pressure (r = 0.73; P < .001) and a negative correlation between right ventricular dyssynchrony and right ventricular fractional area change (r = -0.43; P < .02). Conclusion: HF patients exhibit right ventricular dyssynchrony by strain imaging which correlates with pulmonary hypertension and right ventricular dysfunction.

Original languageEnglish
Pages (from-to)263-267
Number of pages5
JournalJournal of Cardiac Failure
Issue number4
StatePublished - May 2006


  • Echocardiography
  • Pulmonary hypertension
  • Strain

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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