Riluzole improves measures of oxidative stress following traumatic spinal cord injury

Xiaojun Mu; Robert D. Azbill; Joe E. Springer

doi:10.1016/S0006-8993(00)02402-1

Riluzole improves measures of oxidative stress following traumatic spinal cord injury

Xiaojun Mu, Robert D. Azbill, Joe E. Springer

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Rats received a contusion injury to the spinal cord followed by treatment with riluzole (a glutamate release inhibitor, 8 mg/kg), methylprednisolone (MP 30 mg/kg) or both. At 4 h following injury, spinal cords were removed and synaptosomes prepared and examined using five measures of oxidative stress. Riluzole treatment was found to improve mitochondrial function, and enhance glutamate and glucose uptake. As expected, MP treatment was found to reduce lipid peroxidation, but also improved glutamate and glucose uptake. Interestingly, the combination treatment was found to be effective in improving all five measures of oxidative stress. The results of this study clearly demonstrate the potential beneficial effects of a combination approach in the treatment of oxidative stress events in traumatic spinal cord injury.

Original language	English
Pages (from-to)	66-72
Number of pages	7
Journal	Brain Research
Volume	870
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(00)02402-1
State	Published - Jul 7 2000

Bibliographical note

Funding Information:
This work was supported by grants to JES from the NIH (NS-30248 and NS40015) and the Kentucky Spinal Cord and Head Injury Research Trust (SA-9502-K3).

Keywords

Excitotoxicity
Glucocorticoids
Glutamate release
Oxidative stress
Spinal cord trauma

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(00)02402-1

Cite this

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title = "Riluzole improves measures of oxidative stress following traumatic spinal cord injury",

abstract = "Rats received a contusion injury to the spinal cord followed by treatment with riluzole (a glutamate release inhibitor, 8 mg/kg), methylprednisolone (MP 30 mg/kg) or both. At 4 h following injury, spinal cords were removed and synaptosomes prepared and examined using five measures of oxidative stress. Riluzole treatment was found to improve mitochondrial function, and enhance glutamate and glucose uptake. As expected, MP treatment was found to reduce lipid peroxidation, but also improved glutamate and glucose uptake. Interestingly, the combination treatment was found to be effective in improving all five measures of oxidative stress. The results of this study clearly demonstrate the potential beneficial effects of a combination approach in the treatment of oxidative stress events in traumatic spinal cord injury.",

keywords = "Excitotoxicity, Glucocorticoids, Glutamate release, Oxidative stress, Spinal cord trauma",

author = "Xiaojun Mu and Azbill, {Robert D.} and Springer, {Joe E.}",

note = "Funding Information: This work was supported by grants to JES from the NIH (NS-30248 and NS40015) and the Kentucky Spinal Cord and Head Injury Research Trust (SA-9502-K3).",

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AU - Mu, Xiaojun

AU - Azbill, Robert D.

AU - Springer, Joe E.

N1 - Funding Information: This work was supported by grants to JES from the NIH (NS-30248 and NS40015) and the Kentucky Spinal Cord and Head Injury Research Trust (SA-9502-K3).

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Y1 - 2000/7/7

N2 - Rats received a contusion injury to the spinal cord followed by treatment with riluzole (a glutamate release inhibitor, 8 mg/kg), methylprednisolone (MP 30 mg/kg) or both. At 4 h following injury, spinal cords were removed and synaptosomes prepared and examined using five measures of oxidative stress. Riluzole treatment was found to improve mitochondrial function, and enhance glutamate and glucose uptake. As expected, MP treatment was found to reduce lipid peroxidation, but also improved glutamate and glucose uptake. Interestingly, the combination treatment was found to be effective in improving all five measures of oxidative stress. The results of this study clearly demonstrate the potential beneficial effects of a combination approach in the treatment of oxidative stress events in traumatic spinal cord injury.

AB - Rats received a contusion injury to the spinal cord followed by treatment with riluzole (a glutamate release inhibitor, 8 mg/kg), methylprednisolone (MP 30 mg/kg) or both. At 4 h following injury, spinal cords were removed and synaptosomes prepared and examined using five measures of oxidative stress. Riluzole treatment was found to improve mitochondrial function, and enhance glutamate and glucose uptake. As expected, MP treatment was found to reduce lipid peroxidation, but also improved glutamate and glucose uptake. Interestingly, the combination treatment was found to be effective in improving all five measures of oxidative stress. The results of this study clearly demonstrate the potential beneficial effects of a combination approach in the treatment of oxidative stress events in traumatic spinal cord injury.

KW - Excitotoxicity

KW - Glucocorticoids

KW - Glutamate release

KW - Oxidative stress

KW - Spinal cord trauma

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Riluzole improves measures of oxidative stress following traumatic spinal cord injury

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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