RIN4-like proteins mediate resistance protein-derived soybean defense against Pseudomonas syringae

Devarshi Selote, Aardra Kachroo

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Resistance (R) protein mediated recognition of pathogen avirulence effectors triggers signaling that induces a very robust form of species-specific immunity in plants. The soybean Rpg1-b protein mediates this form of resistance against the bacterial blight pathogen, Pseudomonas syringae expressing AvrB Pgyrace4. Likewise, the Arabidopsis RPM1 protein also mediates species-specific resistance against AvrB expressing bacteria. RPM1 and Rpg1-b are non-orthologous and differ in their requirements for downstream signaling components. We recently showed that the activation of Rpg1-b derived resistance signaling requires two host proteins that directly interact with AvrB. These proteins share high sequence similarity with the Arabidopsis RPM1 interacting protein 4 (RIN4), which is essential for RPM1- derived resistance. The two soybean RIN4-like proteins (GmRIN4a and b) differ in their abilities to interact with Rpg1-b as well as to complement the Arabidopsis rin4 mutation. Because the two GmRIN4 proteins interact with each other, we proposed that they might function as a heteromeric complex in mediating Rpg1-b-derived resistance. Absence of GmRIN4a or b enhanced basal resistance against bacterial and oomycete pathogens in soybean. Lack of GmRIN4a also enhanced the virulence of avrB bacteria in plants lacking Rpg1-b. Our studies suggest that multiple RIN4-like proteins proteins mediate R-mediated signaling, in soybean.

Original languageEnglish
JournalPlant Signaling and Behavior
Issue number11
StatePublished - Nov 2010

Bibliographical note

Funding Information:
This work was supported by the United States Department of Agriculture-National Research Initiative (2006–01854) and the United Soybean Board (9244).


  • AvrB
  • Bacterial blight
  • Effector recognition
  • Gaurdee
  • Gene silencing
  • Resistance protein
  • Soybean defense

ASJC Scopus subject areas

  • Plant Science


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