Risk of malignancy in sonographically confirmed ovarian tumors

Rachel Ware Miller, Frederick R. Ueland

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Ovarian cancer is the leading cause of gynecologic cancer death in the United States. Once an ovarian tumor is identified, a pelvic ultrasound is recommended, including tumor volume and tumor structure. Unilocular and simple septate tumors are unlikely to be malignant and when asymptomatic, can be safely followed conservatively without surgery. Complex ovarian tumors are at an increased risk for malignancy and secondary testing is recommended. Secondary testing may include CA125, OVA1, the RMI, ROMA, or the ACOG referral guidelines. When secondary testing indicates that an ovarian tumor is at high risk for malignancy, referral to a gynecologic oncologist is recommended.

Original languageEnglish
Pages (from-to)52-64
Number of pages13
JournalClinical Obstetrics and Gynecology
Issue number1
StatePublished - Mar 2012


  • biomarker testing
  • morphology index
  • ovarian tumors
  • risk of malignancy algorithm
  • risk of malignancy index
  • transvaginal sonography

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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