Risperidone half-life in a patient taking paroxetine: A case report

J. Barnhill; M. T. Susce; F. J. Diaz; Jose De Leon

doi:10.1055/s-2005-873159

Risperidone half-life in a patient taking paroxetine: A case report

J. Barnhill, M. T. Susce, F. J. Diaz, Jose De Leon

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

This case report further establishes the inhibitory effects of paroxetine on risperidone (R) metabolism in a patient whose R was discontinued due to side effects. Baseline through levels in ng/ml were 33 for R, 9 for 9-hydroxyrisperidone (9-OHR) and 42 for the total moiety. The fourth morning after R discontinuation, levels were 4 for R, 1 for 9-OHR and 5 for the total moiety. The estimated half-lives were 23.8 hours for R, 22.8 hours for 9-OHR and 23.5 hours for the total moiety.

Original language	English
Pages (from-to)	223-225
Number of pages	3
Journal	Pharmacopsychiatry
Volume	38
Issue number	5
DOIs	https://doi.org/10.1055/s-2005-873159
State	Published - Sep 2005

ASJC Scopus subject areas

Psychiatry and Mental health
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1055/s-2005-873159

Cite this

@article{233d399fccf3406aad9d631cfb61083b,

title = "Risperidone half-life in a patient taking paroxetine: A case report",

abstract = "This case report further establishes the inhibitory effects of paroxetine on risperidone (R) metabolism in a patient whose R was discontinued due to side effects. Baseline through levels in ng/ml were 33 for R, 9 for 9-hydroxyrisperidone (9-OHR) and 42 for the total moiety. The fourth morning after R discontinuation, levels were 4 for R, 1 for 9-OHR and 5 for the total moiety. The estimated half-lives were 23.8 hours for R, 22.8 hours for 9-OHR and 23.5 hours for the total moiety.",

author = "J. Barnhill and Susce, {M. T.} and Diaz, {F. J.} and {De Leon}, Jose",

year = "2005",

month = sep,

doi = "10.1055/s-2005-873159",

language = "English",

volume = "38",

pages = "223--225",

number = "5",

}

TY - JOUR

T1 - Risperidone half-life in a patient taking paroxetine

T2 - A case report

AU - Barnhill, J.

AU - Susce, M. T.

AU - Diaz, F. J.

AU - De Leon, Jose

PY - 2005/9

Y1 - 2005/9

N2 - This case report further establishes the inhibitory effects of paroxetine on risperidone (R) metabolism in a patient whose R was discontinued due to side effects. Baseline through levels in ng/ml were 33 for R, 9 for 9-hydroxyrisperidone (9-OHR) and 42 for the total moiety. The fourth morning after R discontinuation, levels were 4 for R, 1 for 9-OHR and 5 for the total moiety. The estimated half-lives were 23.8 hours for R, 22.8 hours for 9-OHR and 23.5 hours for the total moiety.

AB - This case report further establishes the inhibitory effects of paroxetine on risperidone (R) metabolism in a patient whose R was discontinued due to side effects. Baseline through levels in ng/ml were 33 for R, 9 for 9-hydroxyrisperidone (9-OHR) and 42 for the total moiety. The fourth morning after R discontinuation, levels were 4 for R, 1 for 9-OHR and 5 for the total moiety. The estimated half-lives were 23.8 hours for R, 22.8 hours for 9-OHR and 23.5 hours for the total moiety.

UR - http://www.scopus.com/inward/record.url?scp=26244457406&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26244457406&partnerID=8YFLogxK

U2 - 10.1055/s-2005-873159

DO - 10.1055/s-2005-873159

M3 - Article

C2 - 16189751

AN - SCOPUS:26244457406

SN - 0176-3679

VL - 38

SP - 223

EP - 225

JO - Pharmacopsychiatry

JF - Pharmacopsychiatry

IS - 5

ER -

Risperidone half-life in a patient taking paroxetine: A case report

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Cite this