Risperidone half-life in a patient taking paroxetine: A case report

J. Barnhill; M. T. Susce; F. J. Diaz; Jose De Leon

doi:10.1055/s-2005-873159

Risperidone half-life in a patient taking paroxetine: A case report

J. Barnhill, M. T. Susce, F. J. Diaz, Jose De Leon

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9 Scopus citations

Abstract

This case report further establishes the inhibitory effects of paroxetine on risperidone (R) metabolism in a patient whose R was discontinued due to side effects. Baseline through levels in ng/ml were 33 for R, 9 for 9-hydroxyrisperidone (9-OHR) and 42 for the total moiety. The fourth morning after R discontinuation, levels were 4 for R, 1 for 9-OHR and 5 for the total moiety. The estimated half-lives were 23.8 hours for R, 22.8 hours for 9-OHR and 23.5 hours for the total moiety.

Original language	English
Pages (from-to)	223-225
Number of pages	3
Journal	Pharmacopsychiatry
Volume	38
Issue number	5
DOIs	https://doi.org/10.1055/s-2005-873159
State	Published - Sep 2005

ASJC Scopus subject areas

Psychiatry and Mental health
Pharmacology (medical)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1055/s-2005-873159

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abstract = "This case report further establishes the inhibitory effects of paroxetine on risperidone (R) metabolism in a patient whose R was discontinued due to side effects. Baseline through levels in ng/ml were 33 for R, 9 for 9-hydroxyrisperidone (9-OHR) and 42 for the total moiety. The fourth morning after R discontinuation, levels were 4 for R, 1 for 9-OHR and 5 for the total moiety. The estimated half-lives were 23.8 hours for R, 22.8 hours for 9-OHR and 23.5 hours for the total moiety.",

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AU - Susce, M. T.

AU - Diaz, F. J.

AU - De Leon, Jose

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AB - This case report further establishes the inhibitory effects of paroxetine on risperidone (R) metabolism in a patient whose R was discontinued due to side effects. Baseline through levels in ng/ml were 33 for R, 9 for 9-hydroxyrisperidone (9-OHR) and 42 for the total moiety. The fourth morning after R discontinuation, levels were 4 for R, 1 for 9-OHR and 5 for the total moiety. The estimated half-lives were 23.8 hours for R, 22.8 hours for 9-OHR and 23.5 hours for the total moiety.

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JO - Pharmacopsychiatry

JF - Pharmacopsychiatry

IS - 5

ER -

Risperidone half-life in a patient taking paroxetine: A case report

Abstract

ASJC Scopus subject areas

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