Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade

Geng Xian Shi, Weikang Cai, Douglas A. Andres

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: Rit signaling promotes cell survival. Results: Rit controls stress-dependent p38-MSK1 signaling and CREB-mediated expression of anti-apoptotic Bcl-2 proteins. Conclusion: Rit regulates a p38-MSK1-CREB survival cascade in cells adapting to stress. Significance: Defining how diverse stimuli induce CREB-dependent gene expression is crucial to understanding complex cellular processes ranging from development to disease.

Original languageEnglish
Pages (from-to)39859-39868
Number of pages10
JournalJournal of Biological Chemistry
Volume287
Issue number47
DOIs
StatePublished - Nov 16 2012

Bibliographical note

Funding Information:
* This work was supported by the United States Public Health Service Grant NS045103 (to D. A. A.) from the National Institute of Neurological Disorders and Stroke and in part by National Institutes of Health Grant P20GM103486 from the National Institute of General Medical Sciences.

Publisher Copyright:
© 2012 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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