Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade

Geng Xian Shi; Weikang Cai; Douglas A. Andres

doi:10.1074/jbc.M112.384248

Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade

Geng Xian Shi, Weikang Cai, Douglas A. Andres

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background: Rit signaling promotes cell survival. Results: Rit controls stress-dependent p38-MSK1 signaling and CREB-mediated expression of anti-apoptotic Bcl-2 proteins. Conclusion: Rit regulates a p38-MSK1-CREB survival cascade in cells adapting to stress. Significance: Defining how diverse stimuli induce CREB-dependent gene expression is crucial to understanding complex cellular processes ranging from development to disease.

Original language	English
Pages (from-to)	39859-39868
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	287
Issue number	47
DOIs	https://doi.org/10.1074/jbc.M112.384248
State	Published - Nov 16 2012

Bibliographical note

Funding Information:
* This work was supported by the United States Public Health Service Grant NS045103 (to D. A. A.) from the National Institute of Neurological Disorders and Stroke and in part by National Institutes of Health Grant P20GM103486 from the National Institute of General Medical Sciences.

Publisher Copyright:
© 2012 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M112.384248

Cite this

@article{9403490d95b241649d892c281eb93af1,

title = "Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade",

abstract = "Background: Rit signaling promotes cell survival. Results: Rit controls stress-dependent p38-MSK1 signaling and CREB-mediated expression of anti-apoptotic Bcl-2 proteins. Conclusion: Rit regulates a p38-MSK1-CREB survival cascade in cells adapting to stress. Significance: Defining how diverse stimuli induce CREB-dependent gene expression is crucial to understanding complex cellular processes ranging from development to disease.",

author = "Shi, {Geng Xian} and Weikang Cai and Andres, {Douglas A.}",

note = "Funding Information: * This work was supported by the United States Public Health Service Grant NS045103 (to D. A. A.) from the National Institute of Neurological Disorders and Stroke and in part by National Institutes of Health Grant P20GM103486 from the National Institute of General Medical Sciences. Publisher Copyright: {\textcopyright} 2012 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.",

year = "2012",

month = nov,

day = "16",

doi = "10.1074/jbc.M112.384248",

language = "English",

volume = "287",

pages = "39859--39868",

number = "47",

}

Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade. / Shi, Geng Xian; Cai, Weikang; Andres, Douglas A.

In: Journal of Biological Chemistry, Vol. 287, No. 47, 16.11.2012, p. 39859-39868.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade

AU - Shi, Geng Xian

AU - Cai, Weikang

AU - Andres, Douglas A.

N1 - Funding Information: * This work was supported by the United States Public Health Service Grant NS045103 (to D. A. A.) from the National Institute of Neurological Disorders and Stroke and in part by National Institutes of Health Grant P20GM103486 from the National Institute of General Medical Sciences. Publisher Copyright: © 2012 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.

PY - 2012/11/16

Y1 - 2012/11/16

N2 - Background: Rit signaling promotes cell survival. Results: Rit controls stress-dependent p38-MSK1 signaling and CREB-mediated expression of anti-apoptotic Bcl-2 proteins. Conclusion: Rit regulates a p38-MSK1-CREB survival cascade in cells adapting to stress. Significance: Defining how diverse stimuli induce CREB-dependent gene expression is crucial to understanding complex cellular processes ranging from development to disease.

AB - Background: Rit signaling promotes cell survival. Results: Rit controls stress-dependent p38-MSK1 signaling and CREB-mediated expression of anti-apoptotic Bcl-2 proteins. Conclusion: Rit regulates a p38-MSK1-CREB survival cascade in cells adapting to stress. Significance: Defining how diverse stimuli induce CREB-dependent gene expression is crucial to understanding complex cellular processes ranging from development to disease.

UR - http://www.scopus.com/inward/record.url?scp=84873950075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873950075&partnerID=8YFLogxK

U2 - 10.1074/jbc.M112.384248

DO - 10.1074/jbc.M112.384248

M3 - Article

C2 - 23038261

AN - SCOPUS:84873950075

VL - 287

SP - 39859

EP - 39868

IS - 47

ER -

Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this