Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade

Geng Xian Shi, Weikang Cai, Douglas A. Andres

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background: Rit signaling promotes cell survival. Results: Rit controls stress-dependent p38-MSK1 signaling and CREB-mediated expression of anti-apoptotic Bcl-2 proteins. Conclusion: Rit regulates a p38-MSK1-CREB survival cascade in cells adapting to stress. Significance: Defining how diverse stimuli induce CREB-dependent gene expression is crucial to understanding complex cellular processes ranging from development to disease.

Original languageEnglish
Pages (from-to)39859-39868
Number of pages10
JournalJournal of Biological Chemistry
Volume287
Issue number47
DOIs
StatePublished - Nov 16 2012

Bibliographical note

Publisher Copyright:
© 2012 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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