TY - JOUR
T1 - Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade
AU - Shi, Geng Xian
AU - Cai, Weikang
AU - Andres, Douglas A.
N1 - Publisher Copyright:
© 2012 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.
PY - 2012/11/16
Y1 - 2012/11/16
N2 - Background: Rit signaling promotes cell survival. Results: Rit controls stress-dependent p38-MSK1 signaling and CREB-mediated expression of anti-apoptotic Bcl-2 proteins. Conclusion: Rit regulates a p38-MSK1-CREB survival cascade in cells adapting to stress. Significance: Defining how diverse stimuli induce CREB-dependent gene expression is crucial to understanding complex cellular processes ranging from development to disease.
AB - Background: Rit signaling promotes cell survival. Results: Rit controls stress-dependent p38-MSK1 signaling and CREB-mediated expression of anti-apoptotic Bcl-2 proteins. Conclusion: Rit regulates a p38-MSK1-CREB survival cascade in cells adapting to stress. Significance: Defining how diverse stimuli induce CREB-dependent gene expression is crucial to understanding complex cellular processes ranging from development to disease.
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U2 - 10.1074/jbc.M112.384248
DO - 10.1074/jbc.M112.384248
M3 - Article
C2 - 23038261
AN - SCOPUS:84873950075
SN - 0021-9258
VL - 287
SP - 39859
EP - 39868
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 47
ER -