Background: Rit signaling promotes cell survival. Results: Rit controls stress-dependent p38-MSK1 signaling and CREB-mediated expression of anti-apoptotic Bcl-2 proteins. Conclusion: Rit regulates a p38-MSK1-CREB survival cascade in cells adapting to stress. Significance: Defining how diverse stimuli induce CREB-dependent gene expression is crucial to understanding complex cellular processes ranging from development to disease.
|Number of pages||10|
|Journal||Journal of Biological Chemistry|
|State||Published - Nov 16 2012|
Bibliographical noteFunding Information:
* This work was supported by the United States Public Health Service Grant NS045103 (to D. A. A.) from the National Institute of Neurological Disorders and Stroke and in part by National Institutes of Health Grant P20GM103486 from the National Institute of General Medical Sciences.
© 2012 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology