RNAA for arsenic, cadmium, copper, and molybdenum in CNS tissues from subjects with age-related neurodegenerative diseases

L. Tandon; B. F. Ni; X. X. Ding; W. D. Ehmann; E. J. Kasarskis; W. R. Markesbery

doi:10.1007/BF02040168

RNAA for arsenic, cadmium, copper, and molybdenum in CNS tissues from subjects with age-related neurodegenerative diseases

L. Tandon, B. F. Ni, X. X. Ding, W. D. Ehmann, E. J. Kasarskis, W. R. Markesbery

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18 Scopus citations

Abstract

Reactor thermal neutron irradiation of biological matrices induces high levels of intense gamma-ray or bremsstrahlung radiation from⁸²Br,⁴²K,²⁴Na, and³²P, that interfere with the determination of As, Cd, Cu, and Mo by INAA. Central nervous system (CNS) issue samples from subjects with Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and controls were analyzed using a simple RNAA procedure involving a rapid two-step solvent extraction procedure to determine these four elements. Significant increases (p≤0.05) in concentrations of Cd and Mo were observed for brain of AD subjects compared to controls, but significant imbalances were not observed for ALS subjects. Concentration data for these elements in selected international reference standards are also presented.

Original language	English
Pages (from-to)	331-339
Number of pages	9
Journal	Journal of Radioanalytical and Nuclear Chemistry Articles
Volume	179
Issue number	2
DOIs	https://doi.org/10.1007/BF02040168
State	Published - Apr 1994

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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title = "RNAA for arsenic, cadmium, copper, and molybdenum in CNS tissues from subjects with age-related neurodegenerative diseases",

abstract = "Reactor thermal neutron irradiation of biological matrices induces high levels of intense gamma-ray or bremsstrahlung radiation from82Br,42K,24Na, and32P, that interfere with the determination of As, Cd, Cu, and Mo by INAA. Central nervous system (CNS) issue samples from subjects with Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and controls were analyzed using a simple RNAA procedure involving a rapid two-step solvent extraction procedure to determine these four elements. Significant increases (p≤0.05) in concentrations of Cd and Mo were observed for brain of AD subjects compared to controls, but significant imbalances were not observed for ALS subjects. Concentration data for these elements in selected international reference standards are also presented.",

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T1 - RNAA for arsenic, cadmium, copper, and molybdenum in CNS tissues from subjects with age-related neurodegenerative diseases

AU - Tandon, L.

AU - Ni, B. F.

AU - Ding, X. X.

AU - Ehmann, W. D.

AU - Kasarskis, E. J.

AU - Markesbery, W. R.

PY - 1994/4

Y1 - 1994/4

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RNAA for arsenic, cadmium, copper, and molybdenum in CNS tissues from subjects with age-related neurodegenerative diseases

Abstract

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