Rod progenitor cells in the mature zebrafish retina

Ann C. Morris, Tamera Scholz, James M. Fadool

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

14 Scopus citations

Abstract

The zebrafish is an excellent model organism in which to study the retina's response to photoreceptor degeneration and/or acute injury. While much has been learned about the retinal stem and progenitor cells that mediate the damage response, several questions remain that cannot be addressed by acute models of injury. The development of genetic models, such as the XOPS-mCFP transgenic line, should further efforts to understand the nature of the signals that promote rod progenitor Rod Progenitor Cells in the Mature Zebrafish Retina proliferation and differentiation following photoreceptor loss. This in turn may help to refine future approaches in higher vertebrates aimed at enhancing retinal progenitor cell activity for therapeutic purposes.

Original languageEnglish
Title of host publicationRecent Advances in Retinal Degeneration
Pages361-368
Number of pages8
DOIs
StatePublished - 2008

Publication series

NameAdvances in Experimental Medicine and Biology
Volume613
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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