Role of Amputation in Improving Mobility, Pain Outcomes, and Emotional and Psychological Well-Being in Children With Metastatic Osteosarcoma

Sebastian Gil, Israel Fernandez-Pineda, Bhaskar Rao, Michael D. Neel, Justin N. Baker, Huiyun Wu, Jianrong Wu, Doralina L. Anghelescu

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: Few studies have analyzed the benefit of limb amputations in children with metastatic osteosarcoma and limited life span. Objective: We studied outcomes of limb amputations in children with metastatic osteosarcoma. Design: We performed a retrospective review of patients who underwent limb amputations (January 1995-June 2015) and died within 1 year of surgery. Setting/Participants: We studied 12 patients with osteosarcoma at a single institution. Measurements: Data on mobility, pain, and emotional and psychological well-being were retrieved from medical records from 1 month before surgery to 6 months after surgery. Results: Of the 12 patients (7 females and 5 males; median age at surgery 13 years [range, 7-20 years]) meeting study criteria, 3 patients and 9 patients had primary osteosarcoma in upper and lower limbs, respectively. Mobility improved postamputation in 8 bedridden/wheelchair-bound patients. Postamputation, emotional, and psychological well-being improved for 9 patients, 3 patients had persistent psychological and/or emotional symptoms, and no patient experienced signs of regret. Daily mean pain scores were significantly lower at 1 week (median 3 [range, 0-6]; P =.03) and 3 months (median 0 [range, 0-8]; P =.02) postsurgery than at 1 week presurgery (median 5.5 [range, 0-10]). Morphine consumption (mg/kg/d) showed a trend toward higher values at 1 week (median 0.2 [range, 0-7.6]; P =.6) and 3 months (median 0.2 [range, 0-0.5]; P =.3) postsurgery than at 1 week presurgery (median 0.1 [range, 0-0.5]). Conclusions: Patients undergoing limb amputations had reduced pain and improved mobility and emotional and psychological well-being. Amputations are likely to benefit children with limited life expectancy.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalAmerican Journal of Hospice and Palliative Medicine
Volume36
Issue number2
DOIs
StatePublished - Feb 1 2019

Bibliographical note

Funding Information:
The authors disclosed receipt of the following financial support for the research and/or authorship of this article This work was supported in part by Grant 5R25CA023944 from the National Cancer Institute and ALSAC, neither of which had any role in its planning, conduct, analysis, or reporting.

Publisher Copyright:
© The Author(s) 2018.

Keywords

  • emotional and psychological well-being
  • end of life
  • limb amputation
  • metastatic osteosarcoma
  • mobility
  • pain

ASJC Scopus subject areas

  • Medicine (all)

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