Role of Amputation in Improving Mobility, Pain Outcomes, and Emotional and Psychological Well-Being in Children With Metastatic Osteosarcoma

Sebastian Gil, Israel Fernandez-Pineda, Bhaskar Rao, Michael D. Neel, Justin N. Baker, Huiyun Wu, Jianrong Wu, Doralina L. Anghelescu

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: Few studies have analyzed the benefit of limb amputations in children with metastatic osteosarcoma and limited life span. Objective: We studied outcomes of limb amputations in children with metastatic osteosarcoma. Design: We performed a retrospective review of patients who underwent limb amputations (January 1995-June 2015) and died within 1 year of surgery. Setting/Participants: We studied 12 patients with osteosarcoma at a single institution. Measurements: Data on mobility, pain, and emotional and psychological well-being were retrieved from medical records from 1 month before surgery to 6 months after surgery. Results: Of the 12 patients (7 females and 5 males; median age at surgery 13 years [range, 7-20 years]) meeting study criteria, 3 patients and 9 patients had primary osteosarcoma in upper and lower limbs, respectively. Mobility improved postamputation in 8 bedridden/wheelchair-bound patients. Postamputation, emotional, and psychological well-being improved for 9 patients, 3 patients had persistent psychological and/or emotional symptoms, and no patient experienced signs of regret. Daily mean pain scores were significantly lower at 1 week (median 3 [range, 0-6]; P =.03) and 3 months (median 0 [range, 0-8]; P =.02) postsurgery than at 1 week presurgery (median 5.5 [range, 0-10]). Morphine consumption (mg/kg/d) showed a trend toward higher values at 1 week (median 0.2 [range, 0-7.6]; P =.6) and 3 months (median 0.2 [range, 0-0.5]; P =.3) postsurgery than at 1 week presurgery (median 0.1 [range, 0-0.5]). Conclusions: Patients undergoing limb amputations had reduced pain and improved mobility and emotional and psychological well-being. Amputations are likely to benefit children with limited life expectancy.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalAmerican Journal of Hospice and Palliative Medicine
Volume36
Issue number2
DOIs
StatePublished - Feb 1 2019

Bibliographical note

Publisher Copyright:
© The Author(s) 2018.

Keywords

  • emotional and psychological well-being
  • end of life
  • limb amputation
  • metastatic osteosarcoma
  • mobility
  • pain

ASJC Scopus subject areas

  • General Medicine

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