Role of Dopamine D1 and D2 Receptors in Novelty-Maintained Place Preference

M. T. Bardo; S. L. Bowling; P. M. Robinet; J. K. Rowlett; M. Lacy; B. A. Mattingly

doi:10.1037/1064-1297.1.1-4.101

Role of Dopamine D₁ and D₂ Receptors in Novelty-Maintained Place Preference

M. T. Bardo, S. L. Bowling, P. M. Robinet, J. K. Rowlett, M. Lacy, B. A. Mattingly

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Rats exposed to 1 of 2 different stimulus compartments showed a preference for the novel compartment. The novelty-maintained place preference was eliminated by the D₁ agonist SKF 38393 and the D₂ agonist quinpirole, but only at doses that also produced an impairment in locomotor activity. The novelty-maintained place preference was also eliminated by the D₁ antagonist SCH 23390, but not by the D₂ antagonist eticlopride. Both of the antagonist drugs tested produced a dose-dependent depression in locomotor activity. However, SCH 23390 was shown to block novelty-maintained place preference at a dose that had no significant effect on locomotor activity. These results indicate that D₁ receptors may play a role in the incentive value of novel stimuli.

Original language	English
Pages (from-to)	101-109
Number of pages	9
Journal	Experimental and Clinical Psychopharmacology
Volume	1
Issue number	1-4
DOIs	https://doi.org/10.1037/1064-1297.1.1-4.101
State	Published - Oct 1993

ASJC Scopus subject areas

Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1037/1064-1297.1.1-4.101

Cite this

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abstract = "Rats exposed to 1 of 2 different stimulus compartments showed a preference for the novel compartment. The novelty-maintained place preference was eliminated by the D1 agonist SKF 38393 and the D2 agonist quinpirole, but only at doses that also produced an impairment in locomotor activity. The novelty-maintained place preference was also eliminated by the D1 antagonist SCH 23390, but not by the D2 antagonist eticlopride. Both of the antagonist drugs tested produced a dose-dependent depression in locomotor activity. However, SCH 23390 was shown to block novelty-maintained place preference at a dose that had no significant effect on locomotor activity. These results indicate that D1 receptors may play a role in the incentive value of novel stimuli.",

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AU - Lacy, M.

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