Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2

Boris Ivandic, Lawrence W. Castellani, Xu Ping Wang, Jian Hua Qiao, Margarete Mehrabian, Mohamad Navab, Alan M. Fogelman, David S. Grass, Mark E. Swanson, Maria C. De Beer, Frederick De Beer, Aldons J. Lusis

Research output: Contribution to journalArticlepeer-review

222 Scopus citations

Abstract

Some observations have suggested that the extracellular group IIa phospholipase A2 (sPLA2), previously implicated in chronic inflammatory conditions such as arthritis, may contribute to atherosclerosis. We have examined this hypothesis by studying transgenic mice expressing the human enzyme. Compared with nontransgenic littermates, the transgenic mice exhibited dramatically increased atherosclerotic lesions when maintained on a high-fat, high-cholesterol diet. Surprisingly the transgenic mice also exhibited significant atherosclerotic lesions when maintained on a low-fat chow diet. Immunohistochemical staining indicated that sPLA2 was present in the atherosclerotic lesions of the transgenic mice. On both chow and atherogenic diets, the transgenic mice exhibited decreased levels of HDLs and slightly increased levels of LDLs compared with nontransgenic littermates. These data indicate that group IIa sPLA2 may promote atherogenesis, in part, through its effects on lipoprotein levels. These data also provide a possible mechanism for the observation that there is an increased incidence of coronary artery disease in many chronic inflammatory diseases.

Original languageEnglish
Pages (from-to)1284-1290
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume19
Issue number5
DOIs
StatePublished - May 1999

Keywords

  • Inflammation
  • Lipoproteins
  • Paraoxonase

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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