Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases

Seonwook Kim; Venkateswaran Subramanian; Ahmed Abdel-Latif; Sangderk Lee

doi:10.1089/met.2019.0120

Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases

Seonwook Kim
, Venkateswaran Subramanian
, Ahmed Abdel-Latif
, Sangderk Lee

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Heparin-binding EGF-like growth factor (HB-EGF) is an EGF family member that interacts with epidermal growth factor receptor (EGFR) and ERBB4. Since HB-EGF was first identified as a novel growth factor secreted from a human macrophage cell line, numerous pathological and physiological functions related to cell proliferation, migration, and inflammation have been reported. Notably, the expression of HB-EGF is sensitively upregulated by oxidative stress in the endothelial cells and functions for auto- and paracrine-EGFR signaling. Overnutrition and obesity cause elevation of HB-EGF expression and EGFR signaling in the hepatic and vascular systems. Modulations of HB-EGF signaling showed a series of protections against phenotypes related to metabolic syndrome and advanced metabolic diseases, suggesting HB-EGF as a potential target against metabolic diseases.

Original language	English
Pages (from-to)	186-196
Number of pages	11
Journal	Metabolic Syndrome and Related Disorders
Volume	18
Issue number	4
DOIs	https://doi.org/10.1089/met.2019.0120
State	Published - May 1 2020

Bibliographical note

Publisher Copyright:
© Copyright 2020, Mary Ann Liebert, Inc., publishers 2020.

Funding

This study was supported by the National Institutes of Health K99/R00 HL105577 (S.L.) and the American Heart Association 17GRNT33700302 (S.L.).

Funders	Funder number
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)	K99HL105577
American the American Heart Association	17GRNT33700302

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HB-EGF
NAFLD
atherosclerosis
endothelial cells
metabolic syndrome

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

Access to Document

10.1089/met.2019.0120

Cite this

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title = "Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases",

abstract = "Heparin-binding EGF-like growth factor (HB-EGF) is an EGF family member that interacts with epidermal growth factor receptor (EGFR) and ERBB4. Since HB-EGF was first identified as a novel growth factor secreted from a human macrophage cell line, numerous pathological and physiological functions related to cell proliferation, migration, and inflammation have been reported. Notably, the expression of HB-EGF is sensitively upregulated by oxidative stress in the endothelial cells and functions for auto- and paracrine-EGFR signaling. Overnutrition and obesity cause elevation of HB-EGF expression and EGFR signaling in the hepatic and vascular systems. Modulations of HB-EGF signaling showed a series of protections against phenotypes related to metabolic syndrome and advanced metabolic diseases, suggesting HB-EGF as a potential target against metabolic diseases.",

keywords = "HB-EGF, NAFLD, atherosclerosis, endothelial cells, metabolic syndrome",

author = "Seonwook Kim and Venkateswaran Subramanian and Ahmed Abdel-Latif and Sangderk Lee",

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doi = "10.1089/met.2019.0120",

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T1 - Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases

AU - Kim, Seonwook

AU - Subramanian, Venkateswaran

AU - Abdel-Latif, Ahmed

AU - Lee, Sangderk

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Heparin-binding EGF-like growth factor (HB-EGF) is an EGF family member that interacts with epidermal growth factor receptor (EGFR) and ERBB4. Since HB-EGF was first identified as a novel growth factor secreted from a human macrophage cell line, numerous pathological and physiological functions related to cell proliferation, migration, and inflammation have been reported. Notably, the expression of HB-EGF is sensitively upregulated by oxidative stress in the endothelial cells and functions for auto- and paracrine-EGFR signaling. Overnutrition and obesity cause elevation of HB-EGF expression and EGFR signaling in the hepatic and vascular systems. Modulations of HB-EGF signaling showed a series of protections against phenotypes related to metabolic syndrome and advanced metabolic diseases, suggesting HB-EGF as a potential target against metabolic diseases.

AB - Heparin-binding EGF-like growth factor (HB-EGF) is an EGF family member that interacts with epidermal growth factor receptor (EGFR) and ERBB4. Since HB-EGF was first identified as a novel growth factor secreted from a human macrophage cell line, numerous pathological and physiological functions related to cell proliferation, migration, and inflammation have been reported. Notably, the expression of HB-EGF is sensitively upregulated by oxidative stress in the endothelial cells and functions for auto- and paracrine-EGFR signaling. Overnutrition and obesity cause elevation of HB-EGF expression and EGFR signaling in the hepatic and vascular systems. Modulations of HB-EGF signaling showed a series of protections against phenotypes related to metabolic syndrome and advanced metabolic diseases, suggesting HB-EGF as a potential target against metabolic diseases.

KW - HB-EGF

KW - NAFLD

KW - atherosclerosis

KW - endothelial cells

KW - metabolic syndrome

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UR - https://www.scopus.com/pages/publications/85084272417#tab=citedBy

U2 - 10.1089/met.2019.0120

DO - 10.1089/met.2019.0120

M3 - Article

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AN - SCOPUS:85084272417

SN - 1540-4196

VL - 18

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JO - Metabolic Syndrome and Related Disorders

JF - Metabolic Syndrome and Related Disorders

IS - 4

ER -

Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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