Role of microglia in postinjury repair and regeneration of the CNS

Alexander G. Rabchevsky, Wolfgang J. Streit

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


The functional roles of microglial cells and brain macrophages are currently under intense scientific scrutiny because these cells are known to be critical elements in the central nervous system's response to injury. Of particular interest are the interactions between microglia and injured neurons, since experimental data suggest that microglia and brain macrophages can have neurotrophic, as well as neurotoxic, effects. In this review, we summarize some of the key observations that have given rise to neurotrophic and neurotoxic theories on microglial cell function. At the same time, we also stress our own experiments involving microglial cell transplants into the injured spinal cord-which strongly support the idea that posttraumatic microgliosis and macrophage formation are critical for postinjury tissue repair, neuron regeneration, and associated neuritic outgrowth.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalMental Retardation and Developmental Disabilities Research Reviews
Issue number3
StatePublished - 1998


  • Axonal growth
  • Brain macrophages
  • Spinal cord injury
  • Transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neuropsychology and Physiological Psychology
  • Genetics(clinical)


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