Role of mitochondrial reactive oxygen species in the activation of cellular signals, molecules, and function

Hiroko P. Indo, Clare L. Hawkins, Ikuo Nakanishi, Ken Ichiro Matsumoto, Hirofumi Matsui, Shigeaki Suenaga, Michael J. Davies, Daret K. St Clair, Toshihiko Ozawa, Hideyuki J. Majima

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

45 Scopus citations


Mitochondria are a major source of intracellular energy and reactive oxygen species in cells, but are also increasingly being recognized as a controller of cell death. Here, we review evidence of signal transduction control by mitochondrial superoxide generation via the nuclear factor-κB (NF-κB) and GATA signaling pathways. We have also reviewed the effects of ROS on the activation of MMP and HIF. There is significant evidence to support the hypothesis that mitochondrial superoxide can initiate signaling pathways following transport into the cytosol. In this study, we provide evidence of TATA signal transductions by mitochondrial superoxide. Oxidative phosphorylation via the electron transfer chain, glycolysis, and generation of superoxide from mitochondria could be important factors in regulating signal transduction, cellular homeostasis, and cell death.

Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
StatePublished - 2017

Publication series

NameHandbook of Experimental Pharmacology
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Bibliographical note

Publisher Copyright:
© Springer International Publishing Switzerland 2016.


  • Activation
  • GATA
  • HIF
  • MMP
  • Mitochondria
  • Mitochondrial ROS
  • MnSOD
  • NF-κB
  • Reactive oxygen species
  • Signal transduction
  • Superoxide

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • Biochemistry


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