Role of Oxidative Stress in Necrotizing Enterocolitis: Advances and Possibilities for Future Therapy

Mandar S. Joshi; Craig A. Nankervis; Michael R. Stenger; Brandon Schanbacher; John Anthony Bauer; Peter J. Giannone

doi:10.1016/B978-0-12-805377-5.00011-4

Role of Oxidative Stress in Necrotizing Enterocolitis: Advances and Possibilities for Future Therapy

Mandar S. Joshi, Craig A. Nankervis, Michael R. Stenger, Brandon Schanbacher, John Anthony Bauer, Peter J. Giannone

Pediatrics

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

During normal fetal development, a balance between the production of oxidants and the antioxidant defense systems is critical for proper growth and development. Studies have shown that an imbalance between oxidant production and antioxidant defense mechanisms may lead to preterm birth, fetal growth restriction, and related morbidities. Premature infants are highly susceptible to oxidant-induced damage due to immature antioxidant defense systems or deficiency of antioxidants. As a result there is an increased risk for the development of oxidant-induced diseases of the newborn, such as bronchopulmonary dysplasia, retinopathy of prematurity, and periventricular leukomalacia.

Original language	English
Title of host publication	Gastrointestinal Tissue
Subtitle of host publication	Oxidative Stress and Dietary Antioxidants
Pages	161-172
Number of pages	12
ISBN (Electronic)	9780128093009
DOIs	https://doi.org/10.1016/B978-0-12-805377-5.00011-4
State	Published - Jan 1 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc. All rights reserved.

Keywords

Antioxidants
Necrotizing enterocolitis
Oxidation
Poly(ADP-ribose)polymerase-1
Transfusion

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-12-805377-5.00011-4

Cite this

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Role of Oxidative Stress in Necrotizing Enterocolitis: Advances and Possibilities for Future Therapy

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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