Role of Oxidative Stress in Necrotizing Enterocolitis: Advances and Possibilities for Future Therapy

Mandar S. Joshi, Craig A. Nankervis, Michael R. Stenger, Brandon Schanbacher, John Anthony Bauer, Peter J. Giannone

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

During normal fetal development, a balance between the production of oxidants and the antioxidant defense systems is critical for proper growth and development. Studies have shown that an imbalance between oxidant production and antioxidant defense mechanisms may lead to preterm birth, fetal growth restriction, and related morbidities. Premature infants are highly susceptible to oxidant-induced damage due to immature antioxidant defense systems or deficiency of antioxidants. As a result there is an increased risk for the development of oxidant-induced diseases of the newborn, such as bronchopulmonary dysplasia, retinopathy of prematurity, and periventricular leukomalacia.

Original languageEnglish
Title of host publicationGastrointestinal Tissue
Subtitle of host publicationOxidative Stress and Dietary Antioxidants
Pages161-172
Number of pages12
ISBN (Electronic)9780128093009
DOIs
StatePublished - Jan 1 2017

Keywords

  • Antioxidants
  • Necrotizing enterocolitis
  • Oxidation
  • Poly(ADP-ribose)polymerase-1
  • Transfusion

ASJC Scopus subject areas

  • Medicine (all)

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