Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking

Sayak Bhattacharya; Kevin E. McElhanon; Liubov V. Gushchina; Noah Weisleder

doi:10.1016/j.lfs.2016.10.018

Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking

Sayak Bhattacharya, Kevin E. McElhanon, Liubov V. Gushchina, Noah Weisleder

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Phosphatidylinositol-4,5-bisphosphate 3-kinases (PI3Ks) are regulatory enzymes involved in the generation of lipid species that modulate cellular signaling pathways through downstream effectors to influence a variety of cellular functions. Years of intensive study of PI3Ks have produced a significant body of literature in many areas, including that PI3K can mediate intracellular vesicular trafficking and through these actions contribute to a number of important physiological functions. This review focuses on the crucial roles that PI3K and AKT, a major downstream partner of PI3K, play in the regulation of vesicle trafficking during various forms of vesicular endocytosis and exocytosis.

Original language	English
Pages (from-to)	39-45
Number of pages	7
Journal	Life Sciences
Volume	167
DOIs	https://doi.org/10.1016/j.lfs.2016.10.018
State	Published - Dec 15 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.

Funding

The authors would like to thank Eric X Beck for his assistance with editing this manuscript. Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number AR063084 (NW). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Additional support was provided through postdoctoral fellowships from the American Heart Association (LG) and The Ohio State University/Nationwide Children’s Hospital Center for Muscle Health and Neuromuscular Disorders (LG, SB).

Funders	Funder number
Ohio State University/Nationwide Children’s Hospital Center for Muscle Health and Neuromuscular Disorders
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases	R01AR063084
American the American Heart Association

Keywords

AKT
Caveolae
Clathrin
Endocytosis
Exocytosis
Membrane trafficking
Phosphatidylinositol-4,5-bisphosphate 3-kinase
PI3K
Protein kinase B

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics

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10.1016/j.lfs.2016.10.018

Cite this

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title = "Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking",

abstract = "Phosphatidylinositol-4,5-bisphosphate 3-kinases (PI3Ks) are regulatory enzymes involved in the generation of lipid species that modulate cellular signaling pathways through downstream effectors to influence a variety of cellular functions. Years of intensive study of PI3Ks have produced a significant body of literature in many areas, including that PI3K can mediate intracellular vesicular trafficking and through these actions contribute to a number of important physiological functions. This review focuses on the crucial roles that PI3K and AKT, a major downstream partner of PI3K, play in the regulation of vesicle trafficking during various forms of vesicular endocytosis and exocytosis.",

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author = "Sayak Bhattacharya and McElhanon, \{Kevin E.\} and Gushchina, \{Liubov V.\} and Noah Weisleder",

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year = "2016",

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doi = "10.1016/j.lfs.2016.10.018",

language = "English",

volume = "167",

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AU - Bhattacharya, Sayak

AU - McElhanon, Kevin E.

AU - Gushchina, Liubov V.

AU - Weisleder, Noah

PY - 2016/12/15

Y1 - 2016/12/15

N2 - Phosphatidylinositol-4,5-bisphosphate 3-kinases (PI3Ks) are regulatory enzymes involved in the generation of lipid species that modulate cellular signaling pathways through downstream effectors to influence a variety of cellular functions. Years of intensive study of PI3Ks have produced a significant body of literature in many areas, including that PI3K can mediate intracellular vesicular trafficking and through these actions contribute to a number of important physiological functions. This review focuses on the crucial roles that PI3K and AKT, a major downstream partner of PI3K, play in the regulation of vesicle trafficking during various forms of vesicular endocytosis and exocytosis.

AB - Phosphatidylinositol-4,5-bisphosphate 3-kinases (PI3Ks) are regulatory enzymes involved in the generation of lipid species that modulate cellular signaling pathways through downstream effectors to influence a variety of cellular functions. Years of intensive study of PI3Ks have produced a significant body of literature in many areas, including that PI3K can mediate intracellular vesicular trafficking and through these actions contribute to a number of important physiological functions. This review focuses on the crucial roles that PI3K and AKT, a major downstream partner of PI3K, play in the regulation of vesicle trafficking during various forms of vesicular endocytosis and exocytosis.

KW - AKT

KW - Caveolae

KW - Clathrin

KW - Endocytosis

KW - Exocytosis

KW - Membrane trafficking

KW - Phosphatidylinositol-4,5-bisphosphate 3-kinase

KW - PI3K

KW - Protein kinase B

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JO - Life Sciences

JF - Life Sciences

ER -

Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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