Role of polyamines and NMDA receptors in ethanol dependence and withdrawal

J. M. Littleton, D. Lovinger, S. Liljequist, R. Ticku, I. Matsumoto, S. Barron

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chair was John M. Littleton. The presentations were (1) Examination of ethanol spermine and acamprosate actions on native and recombinant NMDA receptors, by David Lovinger; (2) Ethanol inhibition of NMDA neurotoxicity on the polyamine site in cerebellar granule cells, by Sture Liljequist; (3) Alterations in expression of NMDA receptor subunits during ethanol exposure and withdrawal, by Raj Ticku; (4) Alterations in polyamine synthesis and release as a potential mechanism for ethanol dependence and withdrawal, by Izuru Matsumoto; (5) The role of polyamines in neurotoxicity induced by alcohol withdrawal in vitro, by John Littleton; and (6) Agmatine reduces some of the effects of "third trimester" alcohol exposure using a rodent model, by Susan Barron.

Original languageEnglish
Pages (from-to)132S-136S
JournalAlcoholism: Clinical and Experimental Research
Issue number5 SUPPL.
StatePublished - 2001


  • Acamprosate
  • Ifenprodil
  • NMDA
  • Neurotoxicity
  • Seizures
  • Subunits

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health


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