Role of renal α-adrenoceptors mediating renin secretion

J. L. Osborn, G. F. DiBona, M. D. Thames

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The increase in renin secretion resulting from low-frequency renal nerve stimulation (0.5 Hz) occurs in blood flow and is apparently derived from a direct effect of renal sympathetic nerves on juxtaglomerular granular cells. We sought to determine the role of renal α-adrenoceptors in this neurally evoked renin secretion. The neurally evoked renin secretion was unaffected by renal α-adrenoceptor blockade with phentolamine or prazosin; however, two dose levels of phenoxybenzamine equally inhibited the renin secretion. The renal vasconstrictor response to graded renal nerve stimulation was similarly diminished by phentolamine, prazosin, and the higher phenoxybenzamine dose, whereas the lower phenoxybenzamine dose was significantly less effective. Renal α-adrenoceptor stimulation with methoxamine infusion at doses that were just subthreshold for altering renal blood flow and urinary sodium excretion or at doses that just reduced urinary sodium excretion also did not change renin secretion. Higher doses of methoxamine that decreased both renal blood flow and sodium excretion increased renin secretion. Based on the inability of phentolamine and prazosin to prevent neurally mediated renin secretion and on the dose-response relationship between methoxamine and changes in renin secretion, renal blood flow, and urinary sodium excretion, we conclude that renal α-adrenoceptors do not mediate renin secretion elicited by direct neural activation of the juxtaglomerular granular cells. The data suggest that phenoxybenzamine inhibits neurally mediated renin secretion by a mechanism other than renal α-adrenoceptor blockade.

Original languageEnglish
Pages (from-to)F620-F626
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Issue number6
StatePublished - 1982

ASJC Scopus subject areas

  • Physiology


Dive into the research topics of 'Role of renal α-adrenoceptors mediating renin secretion'. Together they form a unique fingerprint.

Cite this