Role of SAM chain length in enhancing the sensitivity of nanopillar modified electrodes for glucose detection

Venkataramani Anandan, Rajan Gangadharan, Guigen Zhang

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

In this report, alkanethiol self assembled monolayers (SAM) with two different chain lengths were used to immobilize the functionalizing enzyme (glucose oxidase) onto gold nanopillar modified electrodes and the electrochemical processes of these functionalized electrodes in glucose detection were investigated. First, the formation of these SAMs on the nanopillar modified electrodes was characterized by the cyclic voltammetry and electrochemical impedance spectroscopy techniques, and then the detection sensitivity of these functionalized electrodes to glucose was evaluated by the amperometry technique. Results showed that the SAM of alkanethiols with a longer chain length resulted in a higher degree of surface coverage with less defect and a higher electron transfer resistance, whereas the SAM of alkanethiols with a shorter chain length gave rise to a higher detection sensitivity to glucose. This study sheds some new insight into how to enhance the sensing performance of nanopillar modified electrodes.

Original languageEnglish
Pages (from-to)1295-1305
Number of pages11
JournalSensors
Volume9
Issue number3
DOIs
StatePublished - Mar 2009

Keywords

  • Alkanethiols
  • Biosensors
  • Electrochemical processes
  • Glucose detection
  • Gold nanopillar modified electrodes
  • Self assembled monolayer

ASJC Scopus subject areas

  • Analytical Chemistry
  • Information Systems
  • Instrumentation
  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering
  • Biochemistry

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