Role of serum amyloid a in abdominal aortic aneurysm and related cardiovascular diseases

Preetha Shridas; Avery C. Patrick; Lisa R. Tannock

doi:10.3390/biom11121883

Role of serum amyloid a in abdominal aortic aneurysm and related cardiovascular diseases

Preetha Shridas, Avery C. Patrick, Lisa R. Tannock

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Epidemiological data positively correlate plasma serum amyloid A (SAA) levels with cardiovascular disease severity and mortality. Studies by several investigators have indicated a causal role for SAA in the development of atherosclerosis in animal models. Suppression of SAA attenuates the development of angiotensin II (AngII)-induced abdominal aortic aneurysm (AAA) formation in mice. Thus, SAA is not just a marker for cardiovascular disease (CVD) development, but it is a key player. However, to consider SAA as a therapeutic target for these diseases, the pathway leading to its involvement needs to be understood. This review provides a brief description of the pathobiological significance of this enigmatic molecule. The purpose of this review is to summarize the data relevant to its role in the development of CVD, the pitfalls in SAA research, and unanswered questions in the field.

Original language	English
Article number	1883
Journal	Biomolecules
Volume	11
Issue number	12
DOIs	https://doi.org/10.3390/biom11121883
State	Published - Dec 2021

Bibliographical note

Funding Information:
This work was supported in part by funding from the National Institutes of Health R01 HL147381 and the Department of Veterans Affairs BX004275.

Funding Information:
Author Contributions: P.S. collected the material, wrote, reviewed, edited and responsible for Author Contributions: P.S. collected the material, wrote, reviewed, edited and responsible for fund-ing acquisition; A.C.P. collected literature and responsible forconstructing the figures; L.R.T. re-viewed, edited and responsible for funding acquisition. All authors have read and agreed to the Funding:published Thisversworkion of thewas supportedmanuscript.in part by funding from the National Institutes of Health R01

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Abdominal aortic aneurysm
Cardiovascular disease
HDL
Serum amyloid A

ASJC Scopus subject areas

Biochemistry
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/biom11121883

Cite this

@article{13057f1290454264b890c65c8eddf0f3,

title = "Role of serum amyloid a in abdominal aortic aneurysm and related cardiovascular diseases",

abstract = "Epidemiological data positively correlate plasma serum amyloid A (SAA) levels with cardiovascular disease severity and mortality. Studies by several investigators have indicated a causal role for SAA in the development of atherosclerosis in animal models. Suppression of SAA attenuates the development of angiotensin II (AngII)-induced abdominal aortic aneurysm (AAA) formation in mice. Thus, SAA is not just a marker for cardiovascular disease (CVD) development, but it is a key player. However, to consider SAA as a therapeutic target for these diseases, the pathway leading to its involvement needs to be understood. This review provides a brief description of the pathobiological significance of this enigmatic molecule. The purpose of this review is to summarize the data relevant to its role in the development of CVD, the pitfalls in SAA research, and unanswered questions in the field.",

keywords = "Abdominal aortic aneurysm, Cardiovascular disease, HDL, Serum amyloid A",

author = "Preetha Shridas and Patrick, {Avery C.} and Tannock, {Lisa R.}",

note = "Funding Information: This work was supported in part by funding from the National Institutes of Health R01 HL147381 and the Department of Veterans Affairs BX004275. Funding Information: Author Contributions: P.S. collected the material, wrote, reviewed, edited and responsible for Author Contributions: P.S. collected the material, wrote, reviewed, edited and responsible for fund-ing acquisition; A.C.P. collected literature and responsible forconstructing the figures; L.R.T. re-viewed, edited and responsible for funding acquisition. All authors have read and agreed to the Funding:published Thisversworkion of thewas supportedmanuscript.in part by funding from the National Institutes of Health R01 Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = dec,

doi = "10.3390/biom11121883",

language = "English",

volume = "11",

number = "12",

}

TY - JOUR

T1 - Role of serum amyloid a in abdominal aortic aneurysm and related cardiovascular diseases

AU - Shridas, Preetha

AU - Patrick, Avery C.

AU - Tannock, Lisa R.

N1 - Funding Information: This work was supported in part by funding from the National Institutes of Health R01 HL147381 and the Department of Veterans Affairs BX004275. Funding Information: Author Contributions: P.S. collected the material, wrote, reviewed, edited and responsible for Author Contributions: P.S. collected the material, wrote, reviewed, edited and responsible for fund-ing acquisition; A.C.P. collected literature and responsible forconstructing the figures; L.R.T. re-viewed, edited and responsible for funding acquisition. All authors have read and agreed to the Funding:published Thisversworkion of thewas supportedmanuscript.in part by funding from the National Institutes of Health R01 Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/12

Y1 - 2021/12

N2 - Epidemiological data positively correlate plasma serum amyloid A (SAA) levels with cardiovascular disease severity and mortality. Studies by several investigators have indicated a causal role for SAA in the development of atherosclerosis in animal models. Suppression of SAA attenuates the development of angiotensin II (AngII)-induced abdominal aortic aneurysm (AAA) formation in mice. Thus, SAA is not just a marker for cardiovascular disease (CVD) development, but it is a key player. However, to consider SAA as a therapeutic target for these diseases, the pathway leading to its involvement needs to be understood. This review provides a brief description of the pathobiological significance of this enigmatic molecule. The purpose of this review is to summarize the data relevant to its role in the development of CVD, the pitfalls in SAA research, and unanswered questions in the field.

AB - Epidemiological data positively correlate plasma serum amyloid A (SAA) levels with cardiovascular disease severity and mortality. Studies by several investigators have indicated a causal role for SAA in the development of atherosclerosis in animal models. Suppression of SAA attenuates the development of angiotensin II (AngII)-induced abdominal aortic aneurysm (AAA) formation in mice. Thus, SAA is not just a marker for cardiovascular disease (CVD) development, but it is a key player. However, to consider SAA as a therapeutic target for these diseases, the pathway leading to its involvement needs to be understood. This review provides a brief description of the pathobiological significance of this enigmatic molecule. The purpose of this review is to summarize the data relevant to its role in the development of CVD, the pitfalls in SAA research, and unanswered questions in the field.

KW - Abdominal aortic aneurysm

KW - Cardiovascular disease

KW - HDL

KW - Serum amyloid A

UR - http://www.scopus.com/inward/record.url?scp=85121102491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85121102491&partnerID=8YFLogxK

U2 - 10.3390/biom11121883

DO - 10.3390/biom11121883

M3 - Article

C2 - 34944527

AN - SCOPUS:85121102491

VL - 11

IS - 12

M1 - 1883

ER -

Role of serum amyloid a in abdominal aortic aneurysm and related cardiovascular diseases

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this