Role of skeletal muscle autophagy in high-fat-diet-induced obesity and exercise

Adrienne R. Herrenbruck, Lance M. Bollinger

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Autophagy is a complex degradation pathway responsible for clearing damaged and dysfunctional organelles. High-fat-diet-induced obesity has been shown to alter autophagy throughout the body in a tissue-specific manner. The impact of obesity on skeletal muscle autophagy has yet to be elucidated. This review examines the impact of high-fat-diet-induced obesity and exercise on skeletal muscle autophagy. Better understanding this major quality control mechanism may help develop novel therapies to combat high-fat-diet-induced obesity comorbidities.

Original languageEnglish
Pages (from-to)56-64
Number of pages9
JournalNutrition Reviews
Issue number1
StatePublished - Jan 1 2020

Bibliographical note

Publisher Copyright:
© 2019 The Author(s).


  • Autophagy
  • Exercise
  • High-fat diet
  • Obesity
  • Skeletal muscle

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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