Abstract
Autophagy is a complex degradation pathway responsible for clearing damaged and dysfunctional organelles. High-fat-diet-induced obesity has been shown to alter autophagy throughout the body in a tissue-specific manner. The impact of obesity on skeletal muscle autophagy has yet to be elucidated. This review examines the impact of high-fat-diet-induced obesity and exercise on skeletal muscle autophagy. Better understanding this major quality control mechanism may help develop novel therapies to combat high-fat-diet-induced obesity comorbidities.
| Original language | English |
|---|---|
| Pages (from-to) | 56-64 |
| Number of pages | 9 |
| Journal | Nutrition Reviews |
| Volume | 78 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2020 |
Bibliographical note
Publisher Copyright:© 2019 The Author(s).
Keywords
- Autophagy
- Exercise
- High-fat diet
- Obesity
- Skeletal muscle
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
