Role of surgery and transplantation in the treatment of hepatic metastases from neuroendocrine tumor

Sayee Sundar Alagusundaramoorthy, Roberto Gedaly

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Neuroendocrine tumors (NET) are a heterogeneous group of cancers, with indolent behavior. The most common primary origin is the gastro-intestinal tract but can also appear in the lungs, kidneys, adrenals, ovaries and other organs. In general, NET is usually discovered in the metastatic phase (40%-80%). The liver is the most common organ involved when metastases occur (40%-93%), followed by bone (12%-20%) and lung (8%-10%). A number of different therapeutic options are available for the treatment of hepatic metastases including surgical resection, transplantation, ablation, trans-arterial chemoembolization, chemotherapy and somatostatin analogues. Recently, molecular targeted therapies have been used, usually in combination with other treatment options, to improve outcomes in patients with metastases. This article emphasizes on the role of surgery in the treatment of liver metastases from NET.

Original languageEnglish
Pages (from-to)14348-14358
Number of pages11
JournalWorld Journal of Gastroenterology
Volume20
Issue number39
DOIs
StatePublished - Oct 21 2014

Bibliographical note

Publisher Copyright:
© 2014 Baishideng Publishing Group Inc. All rights reserved.

Keywords

  • Hepatectomy
  • Liver metastases
  • Liver transplantation
  • Neuroendocrine tumors

ASJC Scopus subject areas

  • Gastroenterology

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