Abstract
Thrombospondin 1 (TSP1) is a matricellular glycoprotein that can be secreted by many cell types. Through binding to extracellular proteins and/or cell surface receptors, TSP1 modulates a variety of cellular functions. Since its discovery in 1971, TSP1 has been found to play important roles in multiple biological processes including angiogenesis, apoptosis, latent transforming growth factor-β activation, and immune regulation. Thrombospondin 1 is also involved in regulating many organ functions. However, the role of TSP1 in liver diseases has not been extensively addressed. In this review, we summarize the findings about the possible role that TSP1 plays in chronic liver diseases focusing on non-alcoholic fatty liver diseases, liver fibrosis, and hepatocellular carcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 186-193 |
| Number of pages | 8 |
| Journal | Hepatology Research |
| Volume | 47 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2017 |
Bibliographical note
Funding Information:The work was supported by grants from National Institutes of Health (R01 DK098176 and R01 DK081555 to Wang S) and Grant 132300410012 (to Li Y) from Henan Provincial Science and Technology, China.
Publisher Copyright:
� 2016 The Japan Society of Hepatology
Keywords
- NAFLD
- TGF-β
- TSP1
- angiogenesis
- liver cancer
- liver fibrosis
ASJC Scopus subject areas
- Hepatology
- Infectious Diseases
